FITC标记的三磷酸腺苷结合转运蛋白G超家族成员2抗体

FITC标记的三磷酸腺苷结合转运蛋白G超家族成员2抗体

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  • ¥2980
  • LMAI Bio
  • LM-4780R-FITC
  • 中国/美国/欧洲
  • 2025年07月12日
  • Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200
  • Human, Mouse, Rat, Dog, Horse,
  • Human, Mouse, Rat, Dog, Horse,
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    • 详细信息
    • 技术资料
    • 供应商

      上海联迈生物工程有限公司

    • 库存

      大量

    • 靶点

      详见说明书

    • 级别

      1

    • 目录编号

      LM-4780R-FITC

    • 克隆性

      多克隆

    • 抗原来源

      Rabbit

    • 保质期

      1年

    • 抗体英文名

      Anti-ABCG2/FITC

    • 抗体名

      Anti-ABCG2/FITC

    • 标记物

      FITC标记

    • 宿主

      Human, Mouse, Rat, Dog, Horse,

    • 适应物种

      Human, Mouse, Rat, Dog, Horse,

    • 免疫原

      详见说明书

    • 亚型

      IGg

    • 形态

      粉末、液体、冻干粉

    • 应用范围

      Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200

    • 浓度

      1mg/ml

    • 保存条件

      -20 °C

    • 规格

      100ul

    FITC标记的三磷酸腺苷结合转运蛋白G超家族成员2抗体
    英文名称 Anti-ABCG2/FITC
    中文名称 FITC标记的三磷酸腺苷结合转运蛋白G超家族成员2抗体
    别    名 ABC transporter; ABC15; ABCG 2; ABCG2; ABCG2_HUMAN; ABCP; ATP binding cassette sub family G (WHITE) member 2; ATP binding cassette transporter G2; ATP-binding cassette sub-family G member 2; BCRP; BCRP1; BMDP; Breast cancer resistance protein; CD338; CDw338; CDw338 antigen; EST157481; GOUT1; MGC102821; Mitoxantrone resistance associated protein; Mitoxantrone resistance-associated protein; MRX; Multi drug resistance efflux transport ATP binding cassette sub family G (WHITE) member 2; MXR; MXR1; Placenta specific ATP binding cassette transporter; Placenta specific MDR protein; Placenta-specific ATP-binding cassette transporter; UAQTL1.  
    规格价格 100ul/2980元 购买        大包装/询价
    说 明 书 100ul  
    研究领域 免疫学  神经生物学  干细胞  转录调节因子  转运蛋白  细胞表面分子  
    抗体来源 Rabbit
    克隆类型 Polyclonal
    交叉反应 Human, Mouse, Rat, Dog, Horse, 
    产品应用 Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200  
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量 72kDa
    性    状 Lyophilized or Liquid
    浓    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human ABCG2/CD338
    亚    型 IgG
    纯化方法 affinity purified by Protein A
    储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    产品介绍 background:
    An ABC transporter. Allows efflux of Hoechst dye, a property that has been used to separate bone marrow side population cells, which express BCRP/ABCG2. Appears to play a major role in the multidrug resistance phenotype of a specific MCF-7 breast cancer cell line. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.
    Breast Cancer Resistance Protein (BCRP) is a 70 kDa ATP-Binding Cassette membrane transport protein involved in multidrug resistance. BCRP may be over-expressed in cancer cell lines selected with doxorubicin / verapamil, topotecan or mitoxantrone.


    Function:
    Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.

    Subunit:
    Monomer or homodimer; disulfide-linked.

    Subcellular Location:
    Cell membrane; Multi-pass membrane protein.

    Tissue Specificity:
    Highly expressed in placenta. Low expression in small intestine, liver and colon.

    Similarity:
    Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
    Contains 1 ABC transmembrane type-2 domain.
    Contains 1 ABC transporter domain.

    Database links:

    Entrez Gene: 9429 Human

    Entrez Gene: 26357 Mouse

    Entrez Gene: 397073 Pig

    Entrez Gene: 312382 Rat

    Omim: 603756 Human

    SwissProt: Q9UNQ0 Human

    SwissProt: Q7TMS5 Mouse

    SwissProt: Q8MIB3 Pig

    SwissProt: Q80W57 Rat

    Unigene: 480218 Human

    Unigene: 333096 Mouse

    Unigene: 13131 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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