- ¥1580
- LMAI Bio
- LM-5349R
- 进口/国产
- 2025年12月01日
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- Rabbit
- Human, Rat, Dog, Pig, Cow, Sheep,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-5349R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
phospho-FXYD1 (Ser88)
- 抗体名：
磷酸化磷酸神经膜抗体
- 宿主：
Rabbit
- 适应物种：
Human, Rat, Dog, Pig, Cow, Sheep,
- 免疫原：
KLH conjugated Synthesised phosphopeptide derived from human FXYD1 around the phosphorylation site of Ser88:RL(p-S)TR
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
100ul
| 英文名称 | phospho-FXYD1 (Ser88) |
| 中文名称 | 磷酸化磷酸神经膜抗体 |
| 别 名 | FXYD1 (phospho S88); FXYD1 (phospho Ser88); p-FXYD1 (phospho S88); FXYD domain containing ion transport regulator 1; Phospholemman; PLM; fxyd1; PLM_HUMAN; FXYD domain-containing ion transport regulator 1. |
| 规格价格 | 100ul/1580元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 肿瘤 免疫学 神经生物学 通道蛋白 新陈代谢 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Rat, Dog, Pig, Cow, Sheep, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 10kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human FXYD1 around the phosphorylation site of Ser88:RL(p-S)TR |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: PLM (FXYD1)is a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. PLM may be phosphorylated by several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity. Function: May have a functional role in muscle contraction. Induces a hyperpolarization-activated chloride current when exogenously expressed. Subcellular Location: Membrane; single-pass type I membrane protein Tissue Specificity: Highest expression in skeletal muscle and heart. Moderate levels in brain, placenta, lung, liver, pancreas, uterus, bladder, prostate, small intestine and colon with mucosal lining. Very low levels in kidney, colon and small intestine without mucosa, prostate without endothelial lining, spleen, and testis. Post-translational modifications: Major plasma membrane substrate for cAMP-dependent protein kinase (PK-A) and protein kinase C (PK-C) in several different tissues (By similarity). Phosphorylated in response to insulin and adrenergic stimulation. May be phosphorylated by DMPK. Palmitoylation increases half-life and stability, it is enhanced upon phosphorylation at Ser-88 by PKA. Similarity: Belongs to the FXYD family. SWISS: O00168 Gene ID: 5348 Database links: Entrez Gene: 476487 Dog Entrez Gene: 5348 Human Entrez Gene: 56188 Mouse Entrez Gene: 58971 Rat Omim: 602359 Human SwissProt: P56513 Dog SwissProt: O00168 Human SwissProt: Q9Z239 Mouse SwissProt: O08589 Rat Unigene: 442498 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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【求助】于NF-KB 激活，P65磷酸化位点是ser536还是ser276?
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相关专题 在western blot ting 方面，本文绝对是一个新手，目前正准备磷酸化蛋白的Western，急需这方面的实验技术操作步骤和一些注意事项的指导。在网络上搜集整理了一个western blot实验达人的建议，供大家参考。 我做了很久的western blot ，尤其是phospho-抗体，可以算是达人了。我根据自己的经验，对磷酸化蛋白之western blot提出以下建议，供刚入门的同仁参考
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