- ¥1380 - 2200
- LMAI Bio
- LM-6865R
- 进口/国产
- 2025年12月12日
- IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-6865R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
NALP6
- 抗体名：
富含亮氨酸重复结构域蛋白6抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat,
- 免疫原：
KLH conjugated synthetic peptide derived from human NALP6:301-400/892
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
100ul 200ul
| 英文名称 | NALP6 |
| 中文名称 | 富含亮氨酸重复结构域蛋白6抗体 |
| 别 名 | CLR11.4; NACHT, leucine rich repeat and PYD containing 6; NACHT, LRR and PYD containing protein 6; NACHT, LRR and PYD domains-containing protein 6; NALP6_HUMAN; NLR family, pyrin domain containing 6; Nlrp6; Nucleotide binding oligomerization domain, leucine rich repeat and pyrin domain containing 6; PAN3; PYPAF5; PYRIN containing APAF1 like protein 5; PYRIN-containing APAF1-like protein 5. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 细胞生物 信号转导 细胞凋亡 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 99kDa |
| 细胞定位 | 细胞核 细胞浆 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NALP6:301-400/892 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP6, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008] Function: May contribute to arginine-vasopressin (AVP)-mediated regulation of renal salt-water balance, glucose and lipid metabolism, apoptosis, and/or cell cycle. Isoform 1 binds arginine-vasopressin but not angiotensin II and acts as an arginine-vasopressin V2 receptor. Isoform 2 binds both arginine-vasopressin and angiotensin II and acts as an angiotensin II/vasopressin receptor. Plays a role in modulating inflammatory responses in the colon to allow recovery from intestinal epithelial damage and limit tumorigenic potential. Protects against the development of colitis by controlling the composition of the gut microbiota by preventing colonization of the colon by harmful, inflammation-inducing bacteria such as Prevotella species. May mediate activation of CASP1 via ASC, promote activation of NF-kappa-B and stimulate cAMP accumulation. Subunit: Binds to ASC with its DAPIN domain. Subcellular Location: Isoform 1: Cytoplasm. Cell membrane. Nucleus membrane. Isoform 2: Cytoplasm. Cell membrane. Note=Predominantly expressed in the cell membrane. Tissue Specificity: Highly expressed in the small and large intestine, kidney and liver. Similarity: Belongs to the NLRP family. Contains 1 DAPIN domain. Contains 3 LRR (leucine-rich) repeats. Contains 1 NACHT domain. SWISS: P59044 Gene ID: 171389 Database links: Entrez Gene: 171389 Human Omim: 609650 Human SwissProt: P59044 Human Unigene: 352611 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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在与病原菌的长期斗争中，植物进化出精细、复杂的多层免疫系统保护自身免受侵害。定位于细胞膜表面的植物模式识别受体（Pattern Recognition Receptors，PRRs）作为监控病原菌侵害的「前哨」，通过识别病原菌的病原相关分子模式，激活对多种病原菌的广谱抗性。 PRR 主要是由受体激酶（Receptor Kinases, RKs）和受体蛋白（Receptor-Like Proteins, RLPs）组成。其中重要的一类 PRR 胞外配体识别结构域由富含亮氨酸的重复基序（LRR
Immunity：厦门大学韩家淮团队揭示 PELO 控制 NOD 样受体家族蛋白寡聚化组装和激活的机制
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Toll 样受体结构和分布特点： TLR为I型跨膜糖蛋白，胞外结构域由19―25个前后相连的片段所组成，各片段包括24～29个氨基酸残基，带有x-L-x-x-L-x-L-x-x基序(L为亮氨酸，x为任意氨基酸)，称为富含亮氨酸的重复体(1eucine-richrepeat，LRR)，简称亮氨酸重复序列。整个胞外结构域弯曲成马鞍状，其中的LRR部分构成配体结合区。TLR跨膜分子胞内段为TlR结构域(TIR：Toll／IL-1 receptor)，为所有TLR及IL-1R分子胞内段
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