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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
上海联迈生物工程有限公司
- 库存:
大量
- 目录编号:
LM-5055R
- 克隆性:
多克隆
- 抗原来源:
Rabbit
- 保质期:
1年
- 抗体英文名:
CYP4A22
- 抗体名:
细胞色素P4504A22抗体(脂肪酸Ω羟化酶)
- 宿主:
Rabbit
- 适应物种:
Human, Mouse, Rat, Horse, Rabbit,
- 免疫原:
KLH conjugated synthetic peptide derived from human CYP4A22:51-150/519
- 亚型:
IgG
- 形态:
Lyophilized or Liquid
- 应用范围:
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复)
- 浓度:
1mg/ml
- 保存条件:
Store at -20 °C
- 规格:
100ul 200ul
| 英文名称 | CYP4A22 |
| 中文名称 | 细胞色素P4504A22抗体(脂肪酸Ω羟化酶) |
| 别 名 | CYP4A22; CYPIVA22; Cytochrome P450 4A22; Cytochrome P450 4A22K; Cytochrome P450 family 4 subfamily A polypeptide 22; Fatty acid omega hydroxylase; Lauric acid omega hydroxylase; RP1 18D14.1; CP4AM_HUMAN. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Horse, Rabbit, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 58kDa |
| 细胞定位 | 细胞浆 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CYP4A22:51-150/519 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: Cytochrome P450 4A22 (CYP4A22) is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33. Function: Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate and palmitate. Shows no activity towards arachidonic acid and prostaglandin A1. Lacks functional activity in the kidney and does not contribute to renal 20-hydroxyeicosatetraenoic acid (20-HETE) biosynthesis. Subcellular Location: Endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Microsome membrane; Peripheral membrane protein Similarity: Belongs to the cytochrome P450 family. SWISS: Q5TCH4 Gene ID: 284541 Database links: Entrez Gene: 284541 Human GenBank: NM_001010969 Human Omim: 615341 Human SwissProt: Q5TCH4 Human Unigene: 726474 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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文献和实验2)。 图2 硝基苯和偶氮苯的还原反应 肝微粒体中含有多种水解酶,如酯酶、酰胺酶、糖苷酶等,可分别催化酯类、酰胺类、糖苷类化合物的水解(见图3),以降低或消除其生物活性。 图3 乙酰水杨酸的水解反应 02 Ⅰ相代谢稳定性实验原理 肝药酶CYP即细胞色素P450氧化酶(CYP450),属于单加氧酶(momooxygenase),也称肝微粒体混合功能氧化酶,多位于内质网和线粒体内壁上,参与药物、致癌物、类固醇激素和脂肪酸等多种内、外源性物质代谢。肝药酶CYP氧化还原酶(POR)是所有肝
位置的表示方法有两种,原来用Δ编号系统,近来又规定了ω或(n)编号系统。前者按碳原子的系统序数(从羧基端数起),用双键羧基侧碳原子的序数给双键定位。后者采用碳原子的倒数序数(从甲基端数起),用双键甲基侧碳原子的(倒数)序数给双键定位。这样可将脂肪酸分为代谢相关的4组,即ω3、ω6、ω7、ω9,在哺乳动物体内脂肪酸只能由该族母体衍生而来,各族母体分别是软油酸(16:1,ω7)、油酸(18:1,ω9)、亚油酸(18:2,ω6)和α亚麻酸(18:3,ω3) 哺乳动物体内能合成饱和脂肪酸和单不饱和脂肪酸
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