- ¥780 - 2200
- LMAI Bio
- LM-5768R
- 进口/国产
- 2026年01月07日
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig,
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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-5768R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
FGF23
- 抗体名：
成纤维细胞生长因子23抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig,
- 免疫原：
KLH conjugated synthetic peptide derived from human Fibroblast growth factor 23 N-terminal peptide:
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
50ul 100ul 200ul
| 英文名称 | FGF23 |
| 中文名称 | 成纤维细胞生长因子23抗体 |
| 别 名 | ADHR; FGF-23; Fgf23; FGF 23; FGF23_HUMAN; Fibroblast growth factor 23; Fibroblast growth factor 23 N-terminal peptide; Fibroblast growth factor 23 precursor; HPDR2; HYPF; Phosphatonin; PHPTC; Tumor derived hypophosphatemia inducing factor; Tumor-derived hypophosphatemia-inducing factor. |
 |
Specific References (1) | bs-5768R has been referenced in 1 publications. [IF=3.58] Andersen, Ingrid A., et al. "Elevation of circulating but not myocardial FGF23 in human acute decompensated heart failure." Nephrology Dialysis Transplantation (2015): gfv398. IHC-F ; Human. PubMed:26666498 |
| 规格价格 | 50ul/780元 购买 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 50ul 100ul 200ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 信号转导 干细胞 生长因子和激素 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 27kDa |
| 细胞定位 | 分泌型蛋白 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Fibroblast growth factor 23 N-terminal peptide: |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC). [provided by RefSeq, Feb 2013] Function: Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL. Acts directly on the parathyroid to decrease PTH secretion. Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. Subunit: Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL and heparan sulfate glycosaminoglycans that function as coreceptors. Subcellular Location: Secreted. Note=Secretion is dependent on O-glycosylation. Tissue Specificity: Expressed in osteogenic cells particularly during phases of active bone remodeling. In adult trabecular bone, expressed in osteocytes and flattened bone-lining cells (inactive osteoblasts). Post-translational modifications: Following secretion this protein is inactivated by cleavage into a N-terminal fragment and a C-terminal fragment. The processing is effected by proprotein convertases. O-glycosylated by GALT3. Glycosylation is necessary for secretion; it blocks processing by proprotein convertases when the O-glycan is alpha 2,6-sialylated. Competition between proprotein convertase cleavage and block of cleavage by O-glycosylation determines the level of secreted active FGF23. DISEASE: Defects in FGF23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR) [MIM:193100]. ADHR is characterized by low serum phosphorus concentrations, rickets, osteomalacia, leg deformities, short stature, bone pain and dental abscesses. Defects in FGF23 are a cause of hyperphosphatemic familial tumoral calcinosis (HFTC) [MIM:211900]. HFTC is a severe autosomal recessive metabolic disorder that manifests with hyperphosphatemia and massive calcium deposits in the skin and subcutaneous tissues. Similarity: Belongs to the heparin-binding growth factors family. SWISS: Q9GZV9 Gene ID: 8074 Database links: Entrez Gene: 8074 Human Omim: 605380 Human SwissProt: Q9GZV9 Human Unigene: 287370 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品图片 |  Sample: bone (rat)Lysate at 40 ug Primary: Anti- MRPL32 (bs-5768R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 27kD Observed band size: 27kD |
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文献和实验人成纤维细胞生长因子23（FGF-23） 酶联免疫 分析 试剂 盒使用说明书 本试剂仅供研究使用 目的：本试剂盒用于测定人血清，血浆及相关液体样本中 成纤维细胞生长因子23（FGF-23） 的含量。 实验原理 ： 本试剂盒应用双抗体夹心法测定 标本 中 人 成纤维细胞生长因子23 （ FGF-23 ） 水平。用纯化的 人 成纤维细胞生长因子23 （ FGF-23 ） 抗体包被微孔板，制成固相抗体，往包被单抗的微孔中依次加入
诱人的食用色素，却可能有害健康？何正祥等 Cell 子刊报道其促进肠炎发生的机制！
诱导之前就给予诱惑红，后续再用 IL-23 和诱惑红处理不会诱导肠炎的发生，这是因为在正常条件下，诱惑红可诱导 Treg 细胞介导耐受的发生，而 IL-23 表达的升高阻止了这一过程。 图片来源：Cell MetabolismIL-23 可以调节 CD4+ T 细胞产生细胞因子 IL-17、IL-22 和 IFN-γ。为了搞清楚这些细胞因子是否会影响肠炎的进程，作者利用抗体或基因缺陷小鼠进行了探究。结果发现分泌 IFN-γ 的 CD4+ T 细胞对肠炎的发生有着关键作用。 图片来源：Cell
批次间稳定一致 重组抗体源于一段只编码一种重链和轻链的DNA序列，从而确保抗体的超高纯度。标准化的培养条件下，由哺乳动物细胞表达，保证了抗体质量的批次间稳定性。 图1：对抗体进行质谱分析，数据表明：REAfinity抗体纯度非常高，而杂交瘤来源的抗体是一种混合物。(A)对两个杂交瘤来源的单克隆抗体样本进行质谱分析，可以看出，它们都含有一条分子量接近23,635Da的污染轻链。(B)两个REAfinity抗体样本的质谱分析结果显示，其含有极高纯度的轻链。 通用型同型
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