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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
上海联迈生物工程有限公司
- 库存:
大量
- 目录编号:
LM-6612R
- 克隆性:
多克隆
- 抗原来源:
Rabbit
- 保质期:
1年
- 抗体英文名:
BMP15
- 抗体名:
骨形态发生蛋白15抗体
- 宿主:
Rabbit
- 适应物种:
Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep,
- 免疫原:
KLH conjugated synthetic peptide derived from human BMP15:321-392/392
- 亚型:
IgG
- 形态:
Lyophilized or Liquid
- 应用范围:
WB=1:500-2000 ELISA=1:500-1000 (石蜡切片需做抗原修复)
- 浓度:
1mg/ml
- 保存条件:
Store at -20 °C
- 规格:
50ul 100ul 200ul
| 英文名称 | BMP15 |
| 中文名称 | 骨形态发生蛋白15抗体 |
| 别 名 | BMP 15; BMP-15; BMP15; BMP15_HUMAN; Bone morphogenetic protein 15; GDF 9B; GDF-9B; GDF9B; Growth/differentiation factor 9B; ODG2; POF4. |
| 规格价格 | 50ul/780元 购买 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 50ul 100ul 200ul |
| 研究领域 | 心血管 发育生物学 染色质和核信号 信号转导 干细胞 生长因子和激素 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 14kDa |
| 细胞定位 | 分泌型蛋白 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human BMP15:321-392/392 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: The BMP15 protein is a member of the bone morphogenetic protein family which is part of the transforming growth factor beta superfamily. The transforming growth factor beta superfamily includes large families of growth and differentiation factors. It is thought that BMP15 may be involved in oocyte maturation and follicular development as a homodimer, or by forming heterodimers with a related protein, Gdf9. Function: May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth. Subunit: Homodimer. But, in contrast to other members of this family, cannot be disulfide-linked. Subcellular Location: Secreted. DISEASE: Defects in BMP15 are the cause of ovarian dysgenesis type 2 (ODG2) [MIM:300510]; also known as X-linked hypergonadotropic ovarian dysgenesis or hypergonadotropic ovarian failure due to ovarian dysgenesis. Ovarian dysgenesis leads to ovarian failure and accounts for about half of the cases of primary amenorrhea. Defects in BMP15 are the cause of premature ovarian failure type 4 (POF4) [MIM:300510]. An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. Similarity: Belongs to the TGF-beta family. SWISS: O95972 Gene ID: 9210 Database links: Entrez Gene: 9210 Human Entrez Gene: 12155 Mouse Entrez Gene: 59302 Rat Omim: 300247 Human SwissProt: O95972 Human SwissProt: Q9Z0L4 Mouse Unigene: 532692 Human Unigene: 42160 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品图片 | ![]() Sample: A549(Human) Cell Lysate at 40 ug Primary: Anti-BMP15 (bs-6612R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 14 kD Observed band size: 14 kD |
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文献和实验baifeng1979 请教各位实验高手,我在做重组人骨形态发生蛋白2(rhBMP-2)的体内缓释实验,实验过程是将复合有rhBMP-2的载体材料植入小鼠四肢肌肉内,定期测定体内rhBMP-2的缓释和表达水平,请问采用什么方法更准确、简便,当初想采用ELISA定期测定小鼠外周血清,但有人说小鼠该蛋白与人有较强的同源性,测定值包含有自身BMP,那么如何将内源性和外源性区别开呢。另外,复合rhBMP-2载体材料植入区软组织的该蛋白的表达和定量用组织匀浆ELISA法
肢体再生新突破!治疗 1 天,科学家让断肢青蛙长出了新的腿,运动能力也可恢复
组分析。分析结果显示,与截肢后 7 天的组织相比,11 个小时的组织中的基因表达谱已经发生了显著的变化。利用 MDT 和 ND 的显著差异基因,他们富集出了显著上调和显著下调的信号通路。 图片来源:Science Advances 进一步的基因集富集分析结果显示,组织中前 15 个高度上调信号通路与神经调节、炎症信号传导和细胞形态发生有关。对神经特异性激活相关基因组的进一步研究表明,脑特异性激酶、神经肽的表达、多巴胺受体和神经球蛋白在截肢后 11 小时达到峰值,然后在 24 小时和 7 天后
and mitophagy in lung fibroblasts 的研究论文。 该研究表明,骨形态发生蛋白 4 (BMP4) 在 人肺中的下调,在 IPF 疾病发生和进展中起 关键作用,BMP4 信号通路通过调节肺成 纤维细胞的衰老和线粒体自噬抑制肺纤维 化。因此,BMP4 信号的激活可能是治疗 IPF 肺纤维化的一种新型有效的治疗方法。 血清型:AAV9 注射方式:气管内注射 病毒滴度:1x1010 vp/ml 靶向部位:肺 动物模型:C57BL/6 BMP4+/+ and BMP4+/- mice
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