- ¥1380 - 2200
- LMAI Bio
- LM-5927R
- 进口/国产
- 2025年12月02日
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat, Dog, Cow, Horse, Rabbit,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-5927R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
ANP32C
- 抗体名：
致瘤磷蛋白32相关蛋白1抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Dog, Cow, Horse, Rabbit,
- 免疫原：
KLH conjugated synthetic peptide derived from human ANP32C:81-180/234
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
100ul 200ul
| 英文名称 | ANP32C |
| 中文名称 | 致瘤磷蛋白32相关蛋白1抗体 |
| 别 名 | Acidic (leucine rich) nuclear phosphoprotein 32 family, member C; ANP32 C; Phosphoprotein 32 related protein 1; Tumorigenic protein pp32r1. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 肿瘤 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 26kDa |
| 细胞定位 | 细胞核 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ANP32C:81-180/234 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: The protein encoded by ANP32C is one of at least two proteins that are similar in amino acid sequence to PP32 and are part of the same acidic nuclear phosphoprotein gene family. However, unlike PP32, the encoded protein is tumorigenic. The tumor suppressor function of PP32 has been localized to a 25 amino acid region that is divergent between PP32 and the protein encoded by this gene. This gene does not contain introns. Tissue Specificity: Expressed in activated stem cells, such as mobilized CD34+ cells and cord blood CD34+ cells, but not in resting bone marrow CD34+ cells. Expressed in a variety of neoplastic cell lines, mainly in prostatic adenocarcinoma cell lines. Not expressed in normal prostatic tissue. Similarity: Belongs to the ANP32 family. Contains 4 LRR (leucine-rich) repeats. SWISS: O43423 Gene ID: 23520 Database links: Entrez Gene: 23520 Human Entrez Gene: 448829 Mouse Entrez Gene: 680377 Rat Omim: 606877 Human SwissProt: O43423 Human SwissProt: Q64G17 Mouse Unigene: 661161 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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文献和实验。遗传型视网膜母细胞瘤患者出生时Rb基因的一个等位基因由于生殖细胞突变而丧失功能，出生后如视网膜母细胞中另一个等位基因发生了体细胞突变，这个细胞就会转化为肿瘤细胞。现今在不少的肿瘤均已证实了相应的抑制基因的存在、缺失及其在肿瘤发病中的作用（表9－3）。这些肿瘤在临床上都呈染色体显性遗传方式，但从基因水平上看，它们都是隐性的，因两个等位基因均有突变才能使细胞恶性转化。 视网膜母细胞瘤（Rb）基因定位于13号染色体1区4带，全长约200kb,有27个外显子，编码924个氨基酸的核磷蛋白(Rb
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