- ¥1380 - 2200
- LMAI Bio
- LM-4730R
- 进口/国产
- 2025年11月25日
- WB=1:500-2000 ELISA=1:500-1000 （石蜡切片需做抗原修复）
- Rabbit
- Human
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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-4730R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
NADPH oxidase 4
- 抗体名：
NADPH氧化酶4抗体
- 宿主：
Rabbit
- 适应物种：
Human
- 免疫原：
KLH conjugated synthetic peptide derived from human NOX4:201-300/578 <Extracellular>
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
100ul 200ul
| 英文名称 | NADPH oxidase 4 |
| 中文名称 | NADPH氧化酶4抗体 |
| 别 名 | Kidney oxidase-1; Kidney superoxide-producing NADPH oxidase; KOX 1; KOX; Kox-1; NADPH; NADPH oxidase 4; Nox4; NOX4_HUMAN; Renal NAD(P)H-oxidase; RENOX. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 肿瘤 心血管 细胞生物 免疫学 信号转导 新陈代谢 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 67kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NOX4:201-300/578 <Extracellular> |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: Nox4 is a renal gp91-phox homolog highly expressed at the site of erythropoietin production in the proximal convoluted tubule epithelial cells of the renal cortex. Nox4 is also expressed in fetal tissues, placenta, glioblastoma and vascular cells. Like gp91-phox, the enzymatic activity of Nox4 produces superoxide anions. In vascular cells, the addition of angiotensin II increases Nox4 expression, which suggests a role for Nox-4 in vascular oxidative stress response. Function: Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 4 displays an increased activity. Isoform 5 and isoform 6 display reduced activity. Subunit: Interacts with protein disulfide isomerase (By similarity). Interacts with, relocalizes and stabilizes CYBA/p22phox. Interacts with TLR4. Subcellular Location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein (Probable). Cell junction, focal adhesion (Probable). Nucleus (Probable). Note=May localize to plasma membrane and focal adhesions. According to PubMed:15927447, may also localize to the nucleus. Tissue Specificity: Mainly expressed in heart and skeletal muscle. Also strongly expressed in fetal brain and spinal cord. Post-translational modifications: Isoform 3 and isoform 4 are N-glycosylated. Isoform 4 glycosylation is required for its proper function. Similarity: Contains 1 FAD-binding FR-type domain. Contains 1 ferric oxidoreductase domain. SWISS: Q9NPH5 Gene ID: 50507 Database links: Entrez Gene: 50507 Human Entrez Gene: 50490 Mouse Entrez Gene: 85431 Rat Omim: 605261 Human SwissProt: Q9NPH5 Human SwissProt: Q9JHI8 Mouse SwissProt: Q924V1 Rat Unigene: 371036 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 还原型辅酶烟酰胺腺嘌呤二核苷酸磷酸(NADPH)oxidase 4:还原型辅酶烟胺腺嘌呤二核苷酸（Nicotinamide adenine dinucleotide reduced, NADH）位于线粒体膜内，是细胞能量代谢所必需的辅酶，主要功能是经电子传递链产生ATP。NADH在维持细胞生长、分化和能量代谢中起重要的作用。 |
| 产品图片 |  Sample: A431(Human) Cell Lysate at 30 ug Primary: Anti-NADPH oxidase 4 (bs-4730R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 67 kD Observed band size: 67 kD |
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文献和实验人NADPH氧化酶（NADPH-OX）酶联免疫分析(ELISA)
人 NADPH氧化酶（ NADPH -OX） 酶联免疫 分析(ELISA) 试剂 盒使用说明书 本试剂仅供研究使用 目的：本试剂盒用于测定人血清，血浆，组织及相关液体样本中 NADPH 氧化酶 的活性。 实验原理 ： 本试剂盒应用双抗体夹心法测定 标本 中 人 NADPH氧化酶 水平。用纯化的 人 NADPH氧化酶 抗体包被微孔板，制成固相抗体，往包被单抗的微孔中依次加入 NADPH氧化酶 ，再与HRP 标记
/bitstream/2239/35034/1/NaCl%E5%AF%B9%E5%B0%8F%E9%BA%A6%E6%A0%B9%E8%B4%A8%E8%86%9CNADPH%E6%B0%A7%E5%8C%96%E9%85%B6%E6%B4%BB%E6%80%A7%E7%9A%84%E5%BD%B1%E5%93%8 D .pdf2.http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=158513&blobtype=pdf国外文献中使用较多的NADPH氧化酶
- 抑制。和抗坏血酸氧化酶一起，借助氧使酚类氧化，所产生的苯醌类在醌还原酶的作用下可被谷胱甘肽和 NADPH等还原，构成一种电子传递系统。如果发生象马铃薯块茎切口那样的细胞损伤，由于绿原酸和酪氨酸的氧化产生的醌不能还原，而聚合生成黑素变成褐色。
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