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Sigma货号MAK159-1KT或Sigma货号MAK15
9-1Kit或Sigma货号MAK159线粒体膜电位检测试剂盒(适用于酶标仪)19121878899上海睿安生物Sigma官方正式授权代理- ￥8987.94
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- MAK159
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- 2026年08月05日
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- 文献和实验
- 技术资料
- 保质期：
1年
- 保存条件：
-20°C
- 供应商：
上海睿安生物19121878899
- 库存：
30⁺盒
- 英文名：
Mitochondrial Membrane Potential Kit
- 规格：
500次/盒
Sigma货号MAK159-1KT或Sigma货号MAK159-1Kit或Sigma货号MAK159线粒体膜电位检测试剂盒(适用于酶标仪)19121878899上海睿安生物Sigma官方正式授权代理
线粒体膜电位检测试剂盒(适用于酶标仪)
sufficient for 500 fluorometric tests(microplate readers)
别名:JC-10检测,JC-10线粒体膜蛋白检测
属性
产品名称:线粒体膜电位检测试剂盒(适用于酶标仪),sufficient for 500 fluorometric tests(microplate readers)
usage:sufficient for 500 fluorometric tests (microplate readers)
detection method:fluorometric
relevant disease(s):cancer
storage temp:−20°C
说明
Application
本试剂盒适于检测哺乳动物细胞中的线粒体跨膜电势差(MMP)，并可用于在酶标仪上筛选凋亡抑制剂及激活剂等。线粒体膜电位试剂盒已用于测量线粒体膜电位。
Biochem/physiol Actions
该试剂盒利用JC-10，一种优于JC-1的替代品，用于测定细胞中MMP的损失。尽管JC-1在许多实验室中被广泛使用，但是当其在较高浓度下使用时，其水溶性差通常会导致水性缓冲液沉淀。在较高浓度下，JC-10表现出比JC-1更高的水溶性。与JC-1类似，JC-10是一种阳离子亲脂性染料，其浓缩并在具有极化线粒体膜的细胞线粒体中形成可逆的红色荧光JC-10聚集体(λex=540/λem=590nm)。在凋亡细胞中，MMP崩溃导致JC-10无法保留在线粒体中，并使染料返回到单体绿色荧光形式(λex=490/λem=525nm)。该试剂盒可用于监测细胞凋亡和筛选凋亡抑制剂和激活剂。
General description
由于电子传递链上酶的活动，线粒体在其膜上产生电位。在细胞凋亡过程中，线粒体膜电位(MMP)的崩溃与线粒体通透性转换孔的开放一致，导致细胞色素c释放到细胞质中，进而引发细胞凋亡级联反应的其他下游事件。
同行评审论文(部分:文献)
Development and Evaluation of Paclitaxel and Curcumin Dry Powder for Inhalation Lung Cancer Treatment.
Wing-Hin Lee et al.
Pharmaceutics, 13(1) (2020-12-31)
Despite the effort to develop efficient targeted drug delivery for lung cancer treatment, the outcome remains unsatisfactory with a survival rate of 15% after 5 years of diagnosis. Inhalation formulation is an ideal alternative that could ensure the direct deposition
COX4-1 promotes mitochondrial supercomplex assembly and limits reactive oxide species production in radioresistant GBM.
Claudia R Oliva et al.
Cell stress, 6(4), 45-60 (2022-04-29)
Glioblastoma (GBM) is a fatal disease with recurrences often associated with radioresistance. Although often effective at treating newly diagnosed GBM, increasing evidence suggests that radiotherapy-induced alterations in tumor metabolism promote GBM recurrence and aggressiveness. Using isogenic radiosensitive and radioresistant GBM
A broad-spectrum antibiotic, DCAP, reduces uropathogenic Escherichia coli infection and enhances vorinostat anticancer activity by modulating autophagy.
Giulia Allavena et al.
Cell death & disease, 9(7), 780-780 (2018-07-15)
The cellular recycling pathway of autophagy plays a fundamental role in adaptive responses to nutrient deprivation and other forms of stress under physiological and pathological conditions. However, autophagy can also be a double-edge sword during certain bacterial infections (such as
The mitochondrial membrane potential (deltapsi(m)) in apoptosis.
Jennifer D L, et al.
Apoptosis, 8, 116-128 (2003)
ROS-Mediated Apoptosis Induced by BSA Nanospheres Encapsulated with Fruit Extract of Cucumis prophetarum in Various Human Cancer Cell Lines.
Hemlata et al.
ACS omega, 6(15), 10383-10395 (2021-06-01)
In recent decades, biodegradable polymeric nanoparticles have been used as a nanocarrier for the delivery of anticancer drugs. In the present study, we synthesize bovine serum albumin (BSA) nanospheres and evaluate their ability to incorporate a plant extract with anticancer
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文献和实验该产品被引用文献
Sigma货号MAK159-1KT或Sigma货号MAK159-1Kit或Sigma货号MAK159线粒体膜电位检测试剂盒(适用于酶标仪)19121878899上海睿安生物Sigma官方正式授权代理
线粒体膜电位检测试剂盒(适用于酶标仪)
sufficient for 500 fluorometric tests(microplate readers)
别名:JC-10检测,JC-10线粒体膜蛋白检测
属性
产品名称:线粒体膜电位检测试剂盒(适用于酶标仪),sufficient for 500 fluorometric tests(microplate readers)
usage:sufficient for 500 fluorometric tests (microplate readers)
detection method:fluorometric
relevant disease(s):cancer
storage temp:−20°C
说明
Application
本试剂盒适于检测哺乳动物细胞中的线粒体跨膜电势差(MMP)，并可用于在酶标仪上筛选凋亡抑制剂及激活剂等。线粒体膜电位试剂盒已用于测量线粒体膜电位。
Biochem/physiol Actions
该试剂盒利用JC-10，一种优于JC-1的替代品，用于测定细胞中MMP的损失。尽管JC-1在许多实验室中被广泛使用，但是当其在较高浓度下使用时，其水溶性差通常会导致水性缓冲液沉淀。在较高浓度下，JC-10表现出比JC-1更高的水溶性。与JC-1类似，JC-10是一种阳离子亲脂性染料，其浓缩并在具有极化线粒体膜的细胞线粒体中形成可逆的红色荧光JC-10聚集体(λex=540/λem=590nm)。在凋亡细胞中，MMP崩溃导致JC-10无法保留在线粒体中，并使染料返回到单体绿色荧光形式(λex=490/λem=525nm)。该试剂盒可用于监测细胞凋亡和筛选凋亡抑制剂和激活剂。
General description
由于电子传递链上酶的活动，线粒体在其膜上产生电位。在细胞凋亡过程中，线粒体膜电位(MMP)的崩溃与线粒体通透性转换孔的开放一致，导致细胞色素c释放到细胞质中，进而引发细胞凋亡级联反应的其他下游事件。
同行评审论文(部分:文献)
Development and Evaluation of Paclitaxel and Curcumin Dry Powder for Inhalation Lung Cancer Treatment.
Wing-Hin Lee et al.
Pharmaceutics, 13(1) (2020-12-31)
Despite the effort to develop efficient targeted drug delivery for lung cancer treatment, the outcome remains unsatisfactory with a survival rate of 15% after 5 years of diagnosis. Inhalation formulation is an ideal alternative that could ensure the direct deposition
COX4-1 promotes mitochondrial supercomplex assembly and limits reactive oxide species production in radioresistant GBM.
Claudia R Oliva et al.
Cell stress, 6(4), 45-60 (2022-04-29)
Glioblastoma (GBM) is a fatal disease with recurrences often associated with radioresistance. Although often effective at treating newly diagnosed GBM, increasing evidence suggests that radiotherapy-induced alterations in tumor metabolism promote GBM recurrence and aggressiveness. Using isogenic radiosensitive and radioresistant GBM
A broad-spectrum antibiotic, DCAP, reduces uropathogenic Escherichia coli infection and enhances vorinostat anticancer activity by modulating autophagy.
Giulia Allavena et al.
Cell death & disease, 9(7), 780-780 (2018-07-15)
The cellular recycling pathway of autophagy plays a fundamental role in adaptive responses to nutrient deprivation and other forms of stress under physiological and pathological conditions. However, autophagy can also be a double-edge sword during certain bacterial infections (such as
The mitochondrial membrane potential (deltapsi(m)) in apoptosis.
Jennifer D L, et al.
Apoptosis, 8, 116-128 (2003)
ROS-Mediated Apoptosis Induced by BSA Nanospheres Encapsulated with Fruit Extract of Cucumis prophetarum in Various Human Cancer Cell Lines.
Hemlata et al.
ACS omega, 6(15), 10383-10395 (2021-06-01)
In recent decades, biodegradable polymeric nanoparticles have been used as a nanocarrier for the delivery of anticancer drugs. In the present study, we synthesize bovine serum albumin (BSA) nanospheres and evaluate their ability to incorporate a plant extract with anticancer
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文献支持
Sigma货号MAK159-1KT或Sigma货号MAK159-1Kit或Sigma货号MAK159线粒体膜电位检测试剂盒(适用于酶标仪)19121878899上海睿安生物Sigma官方正式授权代理
￥8987.94
