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- 英国
- ab120481
- 2025年07月15日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
-20°C 干燥
- 保质期：
12个月
- 英文名：
Amyloid β肽(42-1) (人)
- 供应商：
上海汇谱仪器有限公司
- CAS号：
317366-82-8
- 规格：
1 mg
概述
- 产品名称
Amyloid β肽(42-1) (人) - 描述
Inactive control for Amyloid β (1-42) (ab120301)肽
性能
- 分子量
4514.08 - 化学结构
- 分子式
C203H311N55O60S - CAS编号
317366-82-8 - 序列
AIVVGGVMLGIIAGKNSGVDEAFFVLKQHHVEYGSDHRFEAD - 存放说明
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. - 溶解度概述
Soluble in 0.1% NH4OH to 1mg/ml - 处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Amyloid β (42-1) human peptide should be initially dissolved at a concentration of 1mg/ml in 100% HFIP (1,1,1,3,3,3-hexafluoro-2-propanol). This solution should be incubated at room temperature for 1 hour, with occasional vortexing at a moderate speed. Next, the solution should be sonicated for 10 minutes in a water bath sonicator. The HFIP/peptide solution should then be dried under a gentle stream of nitrogen gas. 100% DMSO should be used to re-suspend the peptide. This solution should be incubated at room temperature for 12 minutes, with occasional vortexing. The final solution should then be aliquoted into smaller volumes and stored at -80 °C. For a working solution, add 500-1000 µl of D-PBS (depending on the final concentration to be used) to the peptide stock solution and incubate for 2h at room temperature to allow for peptide aggregation.Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- 来源
Synthetic
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文献和实验Effects of the β-Amyloid Peptide on Membrane Ion Permeability
Several lines of evidence suggest a role for membrane ion channels in the neurotoxic effects of the β-amyloid peptide (Aβ). This chapter describes the electrophysiological techniques that can be employed to isolate and record specific membrane
A detailed understanding of the biochemical events leading to the proteolytic excision of the β-amyloid peptide (A β) from the amyloid precursor protein (APP) has eluded many researchers. This is largely because the measurement of the various APP
病理特征的动物模型。关键词:Alzheimer 病;动物模型;β-淀粉样肽;脑室Alzheimer 病(AD) 是包括遗传因素、慢性感染、免疫缺陷和环境毒素等多种原因引起的神经退行性疾病,其病理特征主要表现为老年斑、神经纤维缠结和神经元丢失。研究显示,β-淀粉样肽(β-amyloid ,Aβ) 是AD发病的早期共同病理促发因素,能引起氧化应激反应的增加,导致AD脑中胆碱能系统功能降低,激活糖原合酶激酶3(Glycogen synthase kinase-3,GSK3β)和促进Tau蛋白的异常磷酸化,介导炎症
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