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- 天津
- TBDCS025210
- 2025年08月03日
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产品编号：TBDCS025210
产品名称：PI3K-mTOR Signaling Cascade Kit
产品规格：25T
产品价格：￥4868.00元
PI3K-mTOR 信号联合检测试剂盒
PI3K-mTOR Signaling Cascade Mapping kit is designed to measure the PI3K and mTOR activities of the PI3K/mTOR signaling cascade simultaneously. The kit provides two fully validated and directly conjugated antibodies against pAkt and pRiboS6 biomarkers. By utilizing both phospho-specific antibodies simultaneously in flow cytometry applications, researchers now have the ability to thoroughly evaluate and dissect two key stages of the PI3K/mTOR signaling cascade for their cancer research.
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文献和实验有 关；（3）一定浓度范围内，HepG2细胞对PI3K/Akt/mTOR信号通路阻断剂的敏感性高于Hep3B细胞，RAPA对PI3K/Akt /mTOR信号通路的部分阻断效应优于LY294002。 目的：观察阿霉素（Doxorubicin，DOX）单用或与RAPA联合用药对HepG2和Hep3B细胞生物学行为及PI3K/Akt/mTOR信号通路活性的影响，探讨mTOR抑制剂增强HCC化疗药物疗效的相关作用机制。 方法：分别取对数生长期的HepG2和Hep3B细胞，以不同浓度的DOX单用
Nat Commun：结直肠癌致癌突变 RNF43_pG659fs 对 PI3K/mTOR 抑制剂敏感
RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition 的研究论文，揭示了 RNF43_p.G659fs 突变在结直肠癌的致癌机制，并对 PI3K/mTOR 抑制剂敏感。 RNF43 是一种 E3 泛素连接酶，Wnt 信号通路的主要负向调节因子，编码 783aa 的锌指蛋白，2014 年 Giannakis 团队在 Nature
Inhibition of PI3K-Akt-mTOR Signaling in Glioblastoma by mTORC1/2 Inhibitors
of rapamycin (mTOR). A serine-threonine kinase, mTOR controls cell growth by regulating mRNA translation, metabolism, and autophagy; acting as both a downstream effector and upstream regulator of PI3K. These signaling functions are distributed
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