组蛋白H2A.X DNA损伤双向检测试剂盒

产品类别：流式细胞检测试剂盒

产品编号：TBDCS025153

产品名称：DNA Damage Histone H2A.X Dual Detection Kit

产品规格：25T

产品价格：￥询价元


组蛋白H2A.X DNA损伤双向检测试剂盒

Histone H2A.X DNA Damage Dual Detection kit includes two directly conjugated antibodies, a phospho-specific Anti-phospho-Histone H2A.X (Ser139)-PerCP and an Anti-Histone H2A.X-FITC conjugated antibody to measure total levels of Histone H2A.X. This two color kit is designed to detect the extent of Histone H2A.X pathway activation by measuring H2A.X phosphorylation relative to the total H2A.X expression in any given cell population. By doing such, the levels of both the total and phosphorylated protein can be measured simultaneously in the same cell, resulting in a normalized and accurate measurement of H2A.X activation after stimulation. Moreover, simultaneous measurement of both total and phospho-Histone H2A.X confirms target specificity of the phosphorylation event. Together, a total and phospho antibody duo performed in multiplex provides an enhanced and more reliable detection of the phospho: total ratio within a mixed 2 cell population. Using this antibody pair provides a sensitive and valuable tool to study the factors that induce DNA damage and/or affect DNA repair, and allow one to explore the linkage between DNA damage, cell cycle checkpoints, and initiation of apoptosis.