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FN1 | Ugl-Y3 Rabbit pAb(bs-134

55R)-50ul/100ul/200ul

价格￥1180 - 2800

品牌Bioss
货号bs-13455R
更新日期2026年10月14日

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规格：
50ul/100ul/200ul

规格：	50ul	产品价格：	￥1180.0
规格：	100ul	产品价格：	￥1980.0
规格：	200ul	产品价格：	￥2800.0

产品编号	bs-13455R
英文名称	Fibronectin/Ugl-Y3 Rabbit pAb
中文名称	纤维连接蛋白/Ugl-Y3抗体
英文别名	CIG; Cold insoluble globulin; DKFZp686F10164; DKFZp686H0342; DKFZp686I1370; DKFZp686O13149; ED B; ED-B; fibronectin 1; FINC; FN 1; FN; FN1; FNZ; GFND; GFND2; LETS; Migration stimulating factor; MSF; Transformation sensitive protein; FINC_HUMAN; Fibronectin; Cold-insoluble globulin; Ugl-Y3.
产品应用	WB=1:500-2000, ICC/IF=1:100-500 Not yet tested in other applications. Optimal working dilutions must be determined by the end user.
交叉反应	Human, Mouse, Rat (Chicken, Dog, Pig, Cow, Horse, Rabbit)
抗体来源	Rabbit
免疫原	KLH conjugated synthetic peptide derived from human Fibronectin/Ugl-Y3
亚型	IgG
性状	Liquid
纯化方法	affinity purified by Protein A
克隆类型	Polyclonal
理论分子量	259 kDa
浓度	1mg/ml
储存液	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域	Cancer > Invasion/microenvironment > ECM > Extracellular matrix Cardiovascular > Angiogenesis > Adhesion / ECM > Extracellular Matrix Developmental Biology > Lineage specification > Ectoderm Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > ECM Proteins > Fibronectin Stem Cells > Lineage Markers > Ectoderm Stem Cells > Mesenchymal Stem Cells > Osteogenesis Stem Cells > Neural Stem Cells > Extracellular
亚基	Mostly heterodimers or multimers of alternatively spliced variants, connected by 2 disulfide bonds near the carboxyl ends; to a lesser extent homodimers. Interacts with FBLN1, AMBP, TNR, LGALS3BP and COL13A1. Interacts with FBLN7. Interacts with COMP. Interacts with S.aureus fnbA. Interacts with TNR; the interaction inhibits cell adhesion and neurite outgrowth. Interacts with FST3.
亚细胞定位	Secreted, extracellular space, extracellular matrix.
组织特异性	Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix. Ugl-Y1, Ugl-Y2 and Ugl-Y3 are found in urine.
翻译后修饰	Sulfated._x000D_ It is not known whether both or only one of Thr-2064 and Thr-2065 are/is glycosylated._x000D_ Forms covalent cross-links mediated by a transglutaminase, such as F13A or TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers (e.g. fibrinogen-fibronectin, collagen-fibronectin heteropolymers)._x000D_ Phosphorylation sites are present in the extracellular medium._x000D_ Proteolytic processing produces the C-terminal NC1 peptide, anastellin.
相似性	Contains 12 fibronectin type-I domains. Contains 2 fibronectin type-II domains. Contains 16 fibronectin type-III domains.
功能	Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape._x000D_ Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.
保存条件	Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料	bs-0666P is a synthetic peptide derived from human Fibronectin. This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008].

应用	推荐稀释比例
{WB}	{1:500-2000}
{ICC/IF}	{1:100-500}

Sample:
_x000D_ Lane 1: Kidney (Mouse) Lysate at 40 ug
_x000D_ Lane 2: Cerebellum (Rat) Lysate at 40 ug
_x000D_ Primary: Anti-Fibronectin/Ugl-Y3 (bs-13455R) at 1/1000 dilution
_x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
_x000D_ Predicted band size: 263 kD
_x000D_ Observed band size: 263 kD

Tissue/cell: HepG2 cell; 4% P‌‌araformaldehyde-fixed; Triton X-100 at room temperature for 20 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Fibronectin/Ugl-Y3) Polyclonal Antibody, Unconjugated (bs-13455R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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