Sample:
Lane 1: Recombinant human Smoothened protein, His lysates
Primary: Anti-Smoothened (bs-2801R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 84 kDa
Observed band size: 28 kDa
- ￥1180 - 2800
- Bioss
- bs-2801R
- 2025年10月16日
- 产品信息以Bioss网站为准
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产品信息以Bioss网站为准
- 规格：
50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-2801R |
| 英文名称 | SMO Rabbit pAb |
| 中文名称 | 跨膜蛋白Smoothened抗体 |
| 英文别名 | Gx; Gx protein; Smoothened; SMOH; Smoothened homolog(Drosophila); Smoothened homolog; Smoothened homolog precursor(SMO)(Gx protein); SMO_HUMAN. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 交叉反应 | Human, Mouse (Rat, Dog, Cow, Horse, Rabbit, Sheep) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human SMO |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 84 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Neuroscience > Neurology process > Neurogenesis Neuroscience > Neurotransmission > Receptors / Channels > GPCR > More GPCR Signal Transduction > Adapters > Transmembrane Signal Transduction > Signaling Pathway > G Protein Signaling > GPCR Stem Cells > Signaling Pathways > Hedgehog > Surface Molecules |
| 亚基 | Interacts with ARRB2. Interacts with KIF7. |
| 亚细胞定位 | Membrane. |
| 相似性 | Belongs to the G-protein coupled receptor Fz/Smo family. Contains 1 FZ (frizzled) domain. |
| 功能 | G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010]Function : G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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文献和实验该产品被引用文献
[IF={{ 5.4 }}] {Smith Claire E. L.. et al. Drug and siRNA screens identify ROCK2 as a therapeutic target for ciliopathies. Communications Medicine. 2025 Apr;5(1):1-18} {IF} {Mouse}
[IF={{ 4.56 }}] {Wang, H., et al. "Baicalin Attenuates Alcoholic Liver Injury through Modulation of Hepatic Oxidative Stress, Inflammation and Sonic Hedgehog Pathway in Rats." Cellular Physiology and Biochemistry 39.3 (2016): 1129-1140.} {WB} {="Rat"}
[IF={{ 4.26 }}] {Zhou et al. GDC-0449 improves the antitumor activity of nano-doxorubicin in pancreatic cancer in a fibroblast-enriched microenvironment. (2017) Sci.Rep. 7:13379} {WB} {Human}
[IF={{ 4.069 }}] {Sato Y et al. Blockade of Hedgehog Signaling Attenuates Biliary Cystogenesis in the Polycystic Kidney (PCK) Rat.Am J Pathol. 2018 Oct;188(10):2251-2263.} {IHC,ICC} {Rat}
[IF={{ 3.8 }}] {Zırh Selim. et al. Investigation of FF-MAS oxysterole’s role in follicular development and its relation to hedgehog signal pathway. SCI REP-UK. 2024 Oct;14(1):1-11} {ELISA} {Human}
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SMO Rabbit pAb(bs-2801R)-50ul/100ul/200ul
￥1180 - 2800
