手机验证
4°C
详见说明
Ropinirole hydrochloride
充足
杭州昊鑫生物
91374-20-8
25mg
生物活性 | Ropinirole (SKF 101468) hydrochloride is an orally active, potent D3/D2 receptor agonist with a Ki of 29 nM for D2 receptor. Ropinirole hydrochloride has pEC50s of 7.4, 8.4 and 6.8 for hD2, hD3 and hD4 receptors, respectively. Ropinirole hydrochloride has no affinity for the D1 receptors. Ropinirole hydrochloride has the potential for Parkinson's disease[1][2]. |
||||
---|---|---|---|---|---|
IC50 & Target[1][2] |
|
体外研究 (In Vitro) |
Ropinirole hydrochloride has affinity for D3 receptors of 10-20 fold higher than the D2 and D4 receptors. Ropinirole hydrochloride is weakly active at alpha 2-adrenoceptors and 5-HT2 receptors but inactive at 5-HT1, benzodiazepine and gamma-aminobutyric acid receptors or alpha 1 and beta-adrenoceptors[1][2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
||||||||
---|---|---|---|---|---|---|---|---|---|
体内研究 (In Vivo) |
Ropinirole (0.1-10 mg/kg; i.p.) decreases intracranial self-stimulation (ICSS) thresholds and induces anxiolytic- and antidepressive-like effects without affecting motor activity or spatial memory[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
|
Clinical Trial |
|
---|
分子量 | 296.84 |
||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Formula | C16H25ClN2O |
||||||||||||||||
CAS 号 | |||||||||||||||||
中文名称 | 盐酸罗匹尼罗 |
||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. |
||||||||||||||||
储存方式 | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
||||||||||||||||
溶解性数据 | In Vitro: H2O : 100 mg/mL (336.88 mM; Need ultrasonic) DMSO : 16.67 mg/mL (56.16 mM; Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
|
风险提示:丁香通仅作为第三方平台,为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全,合理判断,谨慎选购商品,商家和用户对交易行为负责。对于医疗器械类产品,请先查证核实企业经营资质和医疗器械产品注册证情况。