- ￥1700 - 4000
- GeneTex
- 美国
- GTX100444
- 2025年07月12日
- WB, ICC/IF
- Rabbit
- Human, Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Recombinant protein encompassing a sequence within the center region of human p21 Cip1. The exact sequence is proprietary.
- 亚型：
IgG
- 形态：
Liquid
- 保存条件：
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
- 克隆性：
Polyclonal
- 标记物：
Unconjugated
- 适应物种：
Human, Rat
- 保质期：
12 months from the shipping date of the product.
- 抗原来源：
Human
- 目录编号：
GTX100444
- 级别：
Primary Antibodies
- 库存：
Available
- 供应商：
GeneTex
- 宿主：
Rabbit
- 应用范围：
WB, ICC/IF
- 浓度：
1 mg/ml (Please refer to the vial label for the specific concentration.)
- 靶点：
p21 Cip1
- 抗体英文名：
p21 Cip1 antibody
- 抗体名：
p21 Cip1 抗体
- 规格：
100 μl/25 μl
| 规格： | 100 μl | 产品价格： | ￥4000.0 |
|---|---|---|---|
| 规格： | 25 μl | 产品价格： | ￥1700.0 |
p21 Cip1 antibody detects p21 Cip1 protein at nucleus by immunofluorescent analysis.
Samples: HCT116 cells mock (left) and treated with 30 μM Cisplatin for 24 hrs (right) were fixed in 4% PFA at RT for 15 min.
Green: p21 Cip1 protein stained by p21 Cip1 antibody (GTX100444) diluted at 1:1000.
Red: Histone H3S10ph (phospho Ser10), a nucleus marker, stained by Histone H3S10ph (phospho Ser10) antibody [GT921] (GTX630185) diluted at 1:500.
Blue: Hoechst 33342 staining.
Sample (30 μg of whole cell lysate)
A: HCT116
B: HCT116 treated with 30 μM cisplatin for 24 hr
12% SDS PAGE
GTX100444 diluted at 1:1000
The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
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文献和实验Liu YH et al., Sci Rep 2017 (PMID:28134285)
Chen CC et al., PLoS One 2016 (PMID:27977759)
Rodriguez A et al., Theor Biol Med Model 2015 (PMID:26385365)
Chang MC et al., PLoS One 2015 (PMID:26658076)
Feresin RG et al., Food Funct 2016 (PMID:27506987)
So EC et al., Onco Targets Ther 2016 (PMID:27175086)
Chen YJ et al., Life Sci 2013 (PMID:23624232)
Wang SH et al., J Cell Physiol 2012 (PMID:22021110)
Oyama Y et al., PLoS One 2021 (PMID:34161330)
Xu YM et al., Oncotarget 2016 (PMID:26716417)
Liu YH et al., Phytomedicine 2018 (PMID:30097117)
Park SH et al., FASEB J 2018 (PMID:29812969)
Lin KT et al., Am J Chin Med 2018 (PMID:29298516)
Chiu YS et al., Sci Rep 2017 (PMID:29242565)
Briest F et al., Neuroendocrinology 2017 (PMID:28910819)
Salazar G et al., Free Radic Biol Med 2017 (PMID:28363602)
Analysis of p21CDKN1A Recruitment to DNA Excision Repair Foci in the UV-Induced DNA Damage Response
The cyclin-dependent kinase (CDK) inhibitor p21CDKN1A (also known as p21waf1/cip1 ) is a well known player of the G1 and G2 phase cell cycle checkpoints, which are activated in response to DNA damage. In addition, p21 interacts directly
-induced responses, including a down-regulation of the cyclin-dependent kinase (Cdk2) inhibitors p21CIP1 and p27KIP1 , while attachment to P-L-L did not. We conclude that engagement of the FN-receptor integrin α5β1 induces integrin signaling regulating
Quantification of Cell Cycle-Arresting Proteins
blockage is mainly mediated by the persistent upregulation of one or more cyclin-dependent kinase inhibitors (CKIs), including (though not limited to) p16 INK4A and p21 CIP1 and p27 KIP1 . CKIs operate by binding to cyclin-dependent kinases (CDKs
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