- ￥580 - 29180
- Sino Biological
- 北京
- 10704-HNAS
- 2025年08月12日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
-20℃ to -80℃
- 保质期：
12个月
- 英文名：
Recombinant Human Interferon beta / IFN-beta / IFNB Protein
- 库存：
99
- 供应商：
北京义翘神州科技股份有限公司
- 规格：
1.00 mg/5.00 µg/20.00 µg/100.00 µg/500.00 µg
| 规格： | 1.00 mg | 产品价格： | ￥29180.0 |
|---|---|---|---|
| 规格： | 5.00 µg | 产品价格： | ￥580.0 |
| 规格： | 20.00 µg | 产品价格： | ￥1980.0 |
| 规格： | 100.00 µg | 产品价格： | ￥4480.0 |
| 规格： | 500.00 µg | 产品价格： | ￥18480.0 |
蛋白名称：Human Interferon beta / IFN-beta / IFNB Protein
蛋白构建：A DNA sequence encoding the human IFNβ (P01574) (Met1-Asn187) was expressed.
表达宿主：CHO Stable Cells
蛋白纯度：> 95 % as determined by SDS-PAGE
蛋白活性：Measured in antiviral assays using WISH cells infected with vesicular stomatitis virus. The ED50 for this effect is typically 2-20 pg/mL.
蛋白内毒素：< 1.0 EU per μg of the protein as determined by the LAL method
预测N端：Met 22
蛋白分子量：The recombinant human IFNβ consists of 166 amino acids and predicts a molecular mass of 20 KDa. It migrates as an approximately 20-23 KDa band in SDS-PAGE under reducing conditions.
蛋白NP号：P01574
蛋白氨基酸序列：Met1-Asn187
蛋白标签：Native
蛋白保存条件：Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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文献和实验2, Qiu Y, et al. Human Virus-Derived Small RNAs Can Confer Antiviral Immunity in Mammals.Immunity, PubMed ID: 28636969
3, Dai T, et al. FAF1 Regulates Antiviral Immunity by Inhibiting MAVS but Is Antagonized by Phosphorylation upon Viral Infection.Cell host & microbe, PubMed ID: 30472208
4, Yang C, et al. LYAR suppresses interferon-β induction by targeting phosphorylated IRF3.Journal of virology, PubMed ID: 31413131
5, Zhang Z, et al. Acetylation-Dependent Deubiquitinase OTUD3 Controls MAVS Activation in Innate Antiviral Immunity.Molecular cell, PubMed ID: 32679077
6, Fu Z, et al. The complex structure of GRL0617 and SARS-CoV-2 PLpro reveals a hot spot for antiviral drug discovery.Nature communications, PubMed ID: 33473130
7, Chiok K, et al. Human Respiratory Syncytial Virus NS2 Protein Induces Autophagy by Modulating Beclin1 Protein Stabilization and ISGylation.mBio, PubMed ID: 35038909
8, Zhang Y, et al. Allelic imbalance of HLA-B expression in human lung cells infected with coronavirus and other respiratory viruses.European journal of human genetics : EJHG, PubMed ID: 35322240
9, Cao D, et al. The SARS-CoV-2 papain-like protease suppresses type I interferon responses by deubiquitinating STING.Science signaling, PubMed ID: 37130168
10, Zhang Y, et al. Enterovirus D68 infection upregulates SOCS3 expression to inhibit JAK-STAT3 signaling and antagonize the innate interferon response of the host.Virologica Sinica, PubMed ID: 37657555
11, Zou J, et al. Prohibitin1 facilitates viral replication by impairing the RIG-I-like receptor signaling pathway.Journal of virology, PubMed ID: 37754758
12, Yu S-S, et al. Deacetylase Sirtuin 1 mitigates type I IFN- and type II IFN-induced signaling and antiviral immunity.Journal of virology, PubMed ID: 38386781
tumor necrosis factor–{alpha} (TNF-{alpha}), interferon-beta (IFN-beta), and IFN-{gamma} (1). The authors observed that of ~200 miRNAs examined, only miR-155 increased in amount in response to both TLR ligands and IFN-beta. miR-155 accumulated
, microRNA-mediated degradation of transcripts encoding negative regulatory proteins would also abolish PRG expression and restore IFNα responsiveness. Some recent reports showed that interferon beta (IFNβ) stimulation can boost microRNA levels in cell
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