重组人/ 恒河猴/ 食蟹猴/ 狗TGF-beta 1 / TGFB1蛋白产品图

重组人/ 恒河猴/ 食蟹猴/ 狗TGF-beta 1 / TGFB1蛋白

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  • ¥680 - 37960
  • Sino Biological已认证
  • 北京
  • 10804-HNAC
  • 2026年08月31日
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    • 详细信息
    • 询价记录
    • 文献和实验
    • 技术资料
    • 保存条件

      -20℃ to -80℃

    • 保质期

      12个月

    • 英文名

      Human / Rhesus / Cynomolgus / Canine TGF-beta 1 / TGFB1 Protein

    • 库存

      99

    • 供应商

      北京义翘神州科技股份有限公司

    • 规格

      5 µg/20 µg/100 µg/500 µg/1 mg

    规格:5 µg产品价格:¥680.0
    规格:20 µg产品价格:¥699.0
    规格:100 µg产品价格:¥4980.0
    规格:500 µg产品价格:¥16180.0
    规格:1 mg产品价格:¥37960.0
    重组人/ 恒河猴/ 食蟹猴/ 狗TGF-beta 1 / TGFB1蛋白(产品说明)
    蛋白名称:重组人/ 恒河猴/ 食蟹猴/ 狗TGF-beta 1 / TGFB1蛋白
    蛋白构建:A DNA sequence encoding the active form of human / rhesus / cynomolgus / canine TGFβ1 (NP_000651.3) (Ala 279-Ser 390) was expressed and purified. Human, Rhesus, cynomolgus and Canine TGFβ1 sequences are identical.
    表达宿主:CHO Stable Cells
    蛋白纯度:> 95 % as determined by SDS-PAGE.
    生物活性:1.Measured by its ability to inhibit cell proliferation of Mv-1-lu mink lung epithelial cells. The ED50 for this effect is typically 0.01-0.1 ng/mL. 2.Human liver cancer organoids were cultured with FGF2(Cat#10014-HNAE), HGF(Cat#10463-HNAS), FGF7(Cat#10210-H07E), EGF(Cat#50482-MNCH), FGF10(Cat#10573-HNAE), TGFB1(Cat#10804-HNAC), NOG(Cat#50688-M02H), RSPO1(Cat#11083-HNAS). (Routinely tested). Data provided by D1 Medical Technology. 3.Western blot analysis of extracts from serum-starved Hela, untreated(line A) or treated with TGF beta 1 (10804-HNAC) (5 ng/mL, 120min; +)(line B), using Phospho-SMAD2 (Ser465, 467) rabbit monoclonal Antibody (Cat: 110472-R0010) at 1:1000 dilution (upper) or Anti-SMAD2 Antibody, Rabbit polyclonal (Cat: 50727-T58) at 1:100000 dilution (lower) (Routinely tested). 4.Recombinant Human / Rhesus / Cynomolgus / Canine TGF-beta 1 / TGFB1 Protein (Cat: 10804-HNAC) immobilized on CM5 chip, can bind Recombinant Human TGF-beta RIII/TGFBR3 Protein (His Tag) (Cat: 10778-H08H) with an affinity constant of 5.780 nM as determined in an SPR assay (Biacore 8K) (Routinely tested).
    预测N端:Ala 279
    蛋白分子量:The recombinant human / rhesus / cynomolgus / canine TGFβ1 consists of 112 amino acids and has a calculated molecular mass of 12.8 kDa. it migrates as an approximately 13 & 26 kDa band in reduced and non-reduced SDS-PAGE respectively, corresponding to the monomer and homodimer.
    蛋白NP号:NP_000651.3
    蛋白氨基酸序列:Ala279-Ser390

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    图标询价记录
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    图标文献和实验
    该产品被引用文献
    [1]Antagonistic Effect of Erythropoietin Receptor Signaling in Macrophages and Type II Alveolar Epithelial Cells on Pulmonary Fibrosis in Mice.
    PMID:42049419In Vivo2026-05
    [2]Epigenome-wide Mendelian randomization with multi-omics validation identifies epigenetic drivers of idiopathic pulmonary fibrosis.
    PMID:41965819Commun Biol2026-04-11
    [3]Transforming growth factor-β1 downregulates tryptophanyl-tRNA synthetase expression in human lung fibroblasts.
    PMID:41707945Adv Med Sci2026-03
    [4]Regioselective Glycosylation of Demethylbellidifolin by Glycosyltransferase AbCGT Yields Potent Anti-Renal Fibrosis Compound.
    PMID:41599358Molecules2026-01-15
    [5]PLVAP mediates the regulation of the tumour microenvironment in early-stage lung adenocarcinoma.
    PMID:41431249Clin Transl Med2025-12
    [6]Autophagy regulates cellular senescence by mediating the degradation of CDKN1A/p21 and CDKN2A/p16 through SQSTM1/p62-mediated selective autophagy in myxomatous mitral valve degeneration.
    PMID:39988732Autophagy2025-07
    [7]Proteomics and Phosphoproteomics Revealed Dysregulated Kinases and Potential Therapy for Liver Fibrosis.
    PMID:40368138Mol Cell Proteomics2025-06
    [8]Osteoprotegerin is induced by transforming growth factor-beta 1 and regulates pro-fibrotic responses in human dermal fibroblasts.
    PMID:40031101Biochem Biophys Res Commun2025-03
    [9]PIK-III exerts anti-fibrotic effects in activated fibroblasts by regulating p38 activation.
    PMID:39240940PLoS One2024-09-06
    [10]Knockdown of lncRNA MALAT1 attenuates renal interstitial fibrosis through miR-124-3p/ITGB1 axis.
    PMID:37872392Sci Rep2023-10
    相关实验
    • 表观遗传学中组蛋白的修饰

      的作用是调控基因表达。例如组蛋白甲基化多导致基因沉默,去甲基化则相反;乙酰化一般是转录激活,去乙酰化则相反。当然,也可在此基础上产生复杂的生物学效应。例如组蛋白去乙酰化酶 HDAC 可影响免疫系统;H3K4me3、H3K9me2 能够调控记忆的形成, 而且 H3K 甲基化与 X 染色体失活、基因组印记和异染色质形成有关;H3 乙酰化通过多种机制调控以来 ATP 的染色质重塑 ,并参与炎症反应;H2A、H2B 泛素化则与 DNA 损害反应有关;而 H3S28 磷酸化与 H3K27 乙酰化可激活转录

    • 【求助】关于gsk3-beta功能的疑问

      下调不能说明活性降低,因为决定GSK3-beta的活性的还与其磷酸化的比例和磷酸化的位点有关。所以你除了要做GSK3-beta总的蛋白表达之外,还要做磷酸化的GSK3-beta的蛋白表达。 (2)应该活性形式和非活性形式都做。一般来讲,GSK3-beta在Ser9位点磷酸化之后活性收到抑制,而在216位点磷酸化之后,其活性收到加强。因此建议将GSK3-beta的两个磷酸化位点都做了,另外还要同时检测GSK3-beta的总蛋白表达,这样才能全面的说明问题。

    • 国自然/高分文章利器!CRISPR文库筛选保姆级指南:从Cas9递送到表型选择一文打通!

      -1   2、靶向E2F8通过破坏RRM2驱动的DNA修复增敏吉西他滨耐药的胆囊癌对PARP抑制剂的疗效 发表期刊:Journal of Experimental & Clinical Cancer Research 研究机构:复旦大学附属中山医院   研究人员在吉西他滨耐药的NOZ-R胆囊癌细胞中进行了全基因组CRISPR ko筛选(GeCKO v2文库)。敲除转录因子E2F8可显著增强耐药细胞对PARP抑制剂奥拉帕尼的敏感性。机制上,E2F8通过转录上调RRM

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