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重组人 / 恒河猴 / 食蟹猴 / Canine TGF-beta 1 / TGFB1蛋白

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  • ¥680 - 37960
  • Sino Biological已认证
  • 北京
  • 10804-HNAC
  • 2026年01月26日
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    • 详细信息
    • 询价记录
    • 文献和实验
    • 技术资料
    • 保存条件

      -20℃ to -80℃

    • 保质期

      12个月

    • 英文名

      Recombinant Human / Rhesus / Cynomolgus / Canine TGF-beta 1 / TGFB1 Protein

    • 库存

      99

    • 供应商

      北京义翘神州科技股份有限公司

    • 规格

      1.00 mg/5.00 µg/20.00 µg/100.00 µg/500.00 µg

    规格:1.00 mg产品价格:¥37960.0
    规格:5.00 µg产品价格:¥680.0
    规格:20.00 µg产品价格:¥1980.0
    规格:100.00 µg产品价格:¥4980.0
    规格:500.00 µg产品价格:¥16180.0
    重组人 / 恒河猴 / 食蟹猴 / 狗 TGF-beta 1 / TGFB1 蛋白(产品说明)
    蛋白名称:Human / Rhesus / Cynomolgus / Canine TGF-beta 1 / TGFB1 Protein
    蛋白构建:A DNA sequence encoding the active form of human / rhesus / cynomolgus / canine TGFβ1 (NP_000651.3) (Ala 279-Ser 390) was expressed and purified. Human, Rhesus, cynomolgus and Canine TGFβ1 sequences are identical.
    表达宿主:CHO Stable Cells
    蛋白纯度:> 95 % as determined by SDS-PAGE.
    蛋白活性:Measured by its ability to inhibit cell proliferation of Mv-1-lu mink lung epithelial cells. The ED50 for this effect is typically 0.04-0.2 ng/mL.
    蛋白内毒素:< 1.0 EU per μg of the protein as determined by the LAL method
    预测N端:Ala 279
    蛋白分子量:The recombinant human / rhesus / cynomolgus / canine TGFβ1 consists of 112 amino acids and has a calculated molecular mass of 12.8 kDa. it migrates as an approximately 13 & 26 kDa band in reduced and non-reduced SDS-PAGE respectively, corresponding to the monomer and homodimer.
    蛋白NP号:NP_000651.3
    蛋白氨基酸序列:Ala279-Ser390
    蛋白标签:Native
    蛋白保存条件:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

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    • 作者
    • 内容
    • 询问日期
    图标文献和实验
    该产品被引用文献
    1, Liu, S; et al. Sphingomyelin synthase 1 regulates the epithelial‑to‑mesenchymal transition mediated by the TGF‑β/Smad pathway in MDA‑MB‑231 cells. Molecular medicine reports, PMID: 30535436
    2, Zhang, H; et al. Alogliptin alleviates liver fibrosis via suppression of activated hepatic stellate cell. Biochemical and biophysical research communications, PMID: 30797555
    3, Sung, NJ; et al. DHA inhibits Gremlin-1-induced epithelial-to-mesenchymal transition via ERK suppression in human breast cancer cells. Bioscience reports, PMID: 32141512
    4, Chamberlin, T; et al. Obesity reduces mammary epithelial cell TGFβ1 activity through macrophage-mediated extracellular matrix remodeling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, PMID: 32359100
    5, Li, C; et al. Oocytes and hypoxanthine orchestrate the G2-M switch mechanism in ovarian granulosa cells. Development (Cambridge, England), PMID: 32620578
    6, Zhang, X; et al. Roxithromycin attenuates bleomycin-induced pulmonary fibrosis by targeting senescent cells. Acta pharmacologica Sinica, PMID: 33654217
    7, Xia, WP; et al. Knockdown of lncRNA XIST inhibited apoptosis and inflammation in renal fibrosis via microRNA-19b-mediated downregulation of SOX6. Molecular immunology, PMID: 34461493
    8, Wang, H; et al. Downregulation of acylglycerol kinase suppresses high glucose-induced endothelial-mesenchymal transition in HRECs through regulating the LPAR1/TGF-β/Notch signaling pathway. Canadian journal of physiology and pharmacology, PMID: 34559978
    9, Dong, Y; et al. Discovery of a novel DDRs kinase inhibitor XBLJ-13 for the treatment of idiopathic pulmonary fibrosis. Acta pharmacologica Sinica, PMID: 34819618
    10, Zhu, P; et al. ZLN005 Alleviates In Vivo and In Vitro Renal Fibrosis via PGC-1α-Mediated Mitochondrial Homeostasis. Pharmaceuticals (Basel, Switzerland), PMID: 35455432
    11, Li, Z; et al. Luteolin inhibits the TGF-β signaling pathway to overcome bortezomib resistance in multiple myeloma. Cancer letters, PMID: 36442773 1
    2, Feng, Y; et al. Collagen Triple Helix Repeat Containing 1 Deficiency Protects Against Airway Remodeling and Inflammation in Asthma Models In Vivo and In Vitro. Inflammation, PMID: 36640227 1
    3, Ren, Z; et al. Tissue factor overexpression in triple-negative breast cancer promotes immune evasion by impeding T-cell infiltration and effector function. Cancer letters, PMID: 37192729 1
    4, Liu, N; et al. FOSL2 participates in renal fibrosis via SGK1-mediated epithelial-mesenchymal transition of proximal tubular epithelial cells. Journal of translational internal medicine, PMID: 37662889 1
    5, Xia, W; et al. Knockdown of lncRNA MALAT1 attenuates renal interstitial fibrosis through miR-124-3p/ITGB1 axis. Scientific reports, PMID: 37872392 1
    6, Cao, S; et al. Development of dual-mode ELISA based on ALP-catalyzed APP hydrolysis for IL-6 detection. Journal of pharmaceutical and biomedical analysis, PMID: 37783051 1
    7, Wu, W; et al. circGRHPR inhibits aberrant epithelial-mesenchymal transformation progression of lung epithelial cells associated with idiopathic pulmonary fibrosis. Cell biology and toxicology, PMID: 38267743 1
    8, Sanchez, S; et al. PIK-III exerts anti-fibrotic effects in activated fibroblasts by regulating p38 activation. PloS one, PMID: 39240940 1
    9, Feng, J; et al. Enhanced oxidative stress aggravates BLM-induced pulmonary fibrosis by promoting cellular senescence through enhancing NLRP3 activation. Life sciences, PMID: 39393575
    20, McDowell-Sanchez, AK; et al. Osteoprotegerin is induced by transforming growth factor-beta 1 and regulates pro-fibrotic responses in human dermal fibroblasts. Biochemical and biophysical research communications, PMID: 40031101
    21, Tang, Q; et al. Autophagy regulates cellular senescence by mediating the degradation of CDKN1A/p21 and CDKN2A/p16 through SQSTM1/p62-mediated selective autophagy in myxomatous mitral valve degeneration. Autophagy, PMID: 39988732 2
    2, Ma, Y; et al. Plasma-activated solutions prevent peritoneal adhesion formation by regulating eNOS expression in mesothelial cells. Journal of advanced research, PMID: 40020874 2
    3, Zheng, D; et al. CD4+ anti-TGF-β CAR T cells and CD8+ conventional CAR T cells exhibit synergistic antitumor effects. Cell reports. Medicine, PMID: 40107245 2
    4, Cheng, X; et al. Proteomics and phosphoproteomics revealed dysregulated kinases and potential therapy for liver fibrosis. Molecular & cellular proteomics : MCP, PMID: 40368138 2
    5, Wang, A; et al. USP13 promotes hepatic stellate cells activation and aggravates liver fibrosis through deubiquitinating SMAD3. Hepatology international, PMID: 40719972 2
    6, Yuan, S; et al. Liver-targeted degradation of BRD4 reverses hepatic fibrosis and enhances metabolism in murine models. Theranostics, PMID: 40756370 2
    7, Shan, Y; et al. MiR-511-3p upregulates fibrosis-related proteins expression by targeting CAMK2N1 in renal interstitial fibrosis. Life sciences, PMID: 41176218
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    文献支持
    重组人 / 恒河猴 / 食蟹猴 / Canine TGF-beta 1 / TGFB1蛋白
    ¥680 - 37960