- 询价
- Cell Signaling Technology
- 3574
- USA
- 2026年10月15日
- W, IP, IF-IC, F
- Rabbit
- H,M
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- 询价记录
- 文献和实验
- 技术资料
- 抗体英文名：
CD19 Antibody
- 抗原：
synthetic peptide corresponding to residues around the carboxy-terminus of human CD19
- 应用范围：
W, IP, IF-IC, F
- 宿主：
Rabbit
- 适应物种：
H,M
- 保质期：
详见说明书
- 级别：
详见MSDS文件
- 库存：
大量
- 供应商：
CST
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
40 ul (4 western blots)/100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 40 ul (4 western blots) | 产品价格： | ￥请询价 |
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IP=Immunoprecipitation IF-IC=Immunofluorescence (Immunocytochemistry) F=Flow Cytometry
Reactivity Key: H=Human M=Mouse
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W IP IF-IC F | H M | Endogenous | 95 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | CD19 Antibody detects endogenous levels of CD19 independent of its phosphorylated state. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues around the carboxy-terminus of human CD19. Antibodies are purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of SDS extracts from untreated or anti-human IgM treated (12 µg/ml for 2 minutes) Ramos cells and untreated or anti-mouse IgG treated (30 µg/ml for 2 minutes) A20 cells, using control CD19 Antibody. Flow Cytometry
Flow cytometric analysis of Jurkat T cells (blue) and Ramos B cells (green), using CD19 Antibody. IF-IC
Immunofluorescent staining of Ramos cells, using CD19 Antibody (left) or the same antibody preincubated with antigenic peptide (right). |
| Background | CD19 is a 95 kDa coreceptor, which amplifies the signaling cascade in B cells (1). On the B cell surface, CD19 associates with CD21, CD81 and Leu-13 to exert its function. The cytoplasmic tail of CD19 has nine conserved tyrosine residues playing critical roles in CD19 mediated function by coupling signaling molecules to the receptor (1). After B cell receptor or CD19 ligation, Tyr531 and Tyr500 of CD19 are progressively phosphorylated. This phosphorylation enables the coupling of PI3 kinase and Src family tyrosine kinase to CD19 and activates the PI3K and Src signaling pathways (2,3). Coligation of B cell receptor and CD19 also promotes Tyr409 phosphorylation in CD19. The phosphorylation at these sites enables its binding to Vav and mediates elevated intracellular calcium response, as well as the JNK pathway (4,5). |
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验thresholds for antigen receptors and other surface receptors on B cells; also regulates B cell development, activation and differentiation CD19 antibody inhibits B cell activation from anti-immunoglobulin Coreceptor with CD21 Earliest B cell
Generation of Antibody Molecules Through Antibody Engineering
been overcome to a large extent using genetic-engineering techniques to produce chimeric mouse/human and completely human antibodies. Such an approach is particularly suitable because of the domain structure of the antibody molecule ( 2 ), where functional
CD19 ／ CD81 白细胞分化抗原及其功能 CDl9 CDl9分子胞膜外区结构属IgSF，包括2个C2样区，胞质区较长，不同种属间有很高的同源性，含有可发生磷酸化的丝／苏氨酸和酪氨酸残基。CDl9分子分布于除浆细胞外的B细胞谱系发育的各个阶段，也是与B细胞识别、黏附和活化有关的CD分子的结构B细胞的重要标记。 此外CDl9还表达于生发中心的FDC，以及某些急性髓细胞白血病细胞。CDl9是CDl9／CD21／CD81信号复合
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