ATM (D2E2) Rabbit mAb产品图

ATM (D2E2) Rabbit mAb

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  • 询价
  • Cell Signaling Technology已认证
  • USA
  • 2026年05月28日
  • W
  • H,M
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 抗体英文名:

      ATM (D2E2) Rabbit mAb

    • 抗原:

      recombinant human ATM

    • 应用范围:

      W

    • 保质期:

      详见说明书

    • 级别:

      详见MSDS文件

    • 适应物种:

      H,M

    • 供应商:

      CST

    • 库存:

      大量

    • 是否单克隆:

      1

    • 保存条件:

      -20°c

    • 规格:

      100 ul (10 western blots)/carrier free & custom formulation / quantity

    规格:产品价格:¥请询价
    规格:100 ul (10 western blots)产品价格:¥请询价
    规格:carrier free & custom formulation / quantity产品价格:¥请询价

    pathway more info application references datasheet PDF MSDS PDF protocols

    Applications Key:  W=Western Blotting
    Reactivity Key:  H=Human  M=Mouse
    Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.

    Applications Reactivity Sensitivity MW (kDa) Isotype
    W H M Endogenous 350 Rabbit IgG
    Protocols
    Specificity / Sensitivity

    ATM (D2E2) Rabbit mAb detects endogenous levels of total ATM protein.

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with recombinant human ATM.

    Western Blotting

    Western Blotting

    Western blot analysis of extracts of HeLa, NCCIT and PYS2 cells using ATM (D2E2) Rabbit mAb.

    Background

    Ataxia telangiectasia mutated kinase (ATM) is a serine/threonine kinase that regulates cell cycle checkpoints and DNA repair (1). Activation of ATM by autophosphorylation on Ser1981 occurs in response to exposed DNA double stranded breaks. ATM kinase regulates a number of proteins involved in cell cycle checkpoint control, apoptosis, and DNA repair. Known substrates include p53, Chk2, Chk1, CtIP, 4E-BP1, BRCA1, RPA3, H2A.X, SMC1, FANCD2, Rad17, Artemis, Nbs1, and the I-2 regulatory subunit of PP1 (1,2). Mutations in the corresponding ATM gene result in ataxia telangiectasia (AT), an autosomal recessive disease characterized by uncoordinated muscle movement and neurodegeneration. Cells from AT patients display defective DNA damage-induced checkpoint activation, sensitivity to radiation, and a higher frequency of chromosome breakage (3,4).

    1. Lee, J.H. and Paull, T.T. (2007) Oncogene 26, 7741-8.
    2. Tang, X. et al. (2008) Mol Cell Biol 28, 2559-66.
    3. Shiloh, Y. (1997) Annu Rev Genet 31, 635-62.
    4. Petrini, J.H. (2000) Curr Opin Cell Biol 12, 293-6.
    Application References

    Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know !

    Companion Products

    For Research Use Only. Not For Use In Diagnostic Procedures.

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    图标文献和实验
    该产品被引用文献
    [1]Altered MDC1 Interactions and Dysfunctional DNA Repair in Lobular Breast Cancer Confers Sensitivity to PARP Inhibition
    PMID:41512199Cancer Res2026-04
    [2]SIRT1 regulates dermal fibroblast senescence via impaired deacetylase function and mitochondrial dysfunction during skin aging induced by chronic oral cadmium exposure.
    PMID:41815959Front Public Health2026-02-24
    [3]Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss.
    PMID:40464565Cancer Res Commun2025-06-01
    [4]The histone acetyltransferase CBP participates in regulating the DNA damage response through ATM after double-strand breaks
    PMID:40200339Genome Biol2025-04-08
    [5]ODF2L acts as a synthetic lethal partner with WEE1 inhibition in epithelial ovarian cancer models
    PMID:36378528J Clin Invest2023-01-17
    [6]Compartmentalisation of Hepatitis B virus X gene evolution in hepatocellular carcinoma microenvironment and the genotype-phenotype correlation of tumorigenicity in HBV-related patients with hepatocellular carcinoma
    PMID:36102940Emerg Microbes Infect2022-12
    [7]Inhibition of XPO1 Sensitizes Small Cell Lung Cancer to First- and Second-Line Chemotherapy
    PMID:34815254Cancer Res2022-02-01
    [8]Phosphorylation of seryl-tRNA synthetase by ATM/ATR is essential for hypoxia-induced angiogenesis.
    PMID:33351793PLoS Biol2020-12-22
    [9]Low-Dose Hsp90 Inhibitor Selectively Radiosensitizes HNSCC and Pancreatic Xenografts
    PMID:32718999Clin Cancer Res2020-10-01
    [10]Targeting Angiogenesis by Blocking the ATM-SerRS-VEGFA Pathway for UV-Induced Skin Photodamage and Melanoma Growth.
    PMID:31766690Cancers (Basel)2019-11-22
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