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- 详细信息
- 技术资料
- 形态:
液态/粉状
- 保存条件:
-20℃保存
- 克隆性:
多克隆
- 标记物:
见说明书
- 适应物种:
人,大鼠,小鼠,兔
- 宿主:
Goat,Rabbit,Mouse
- 应用范围:
科研使用
- 浓度:
1mg/1ml
- 靶点:
来电咨询
- CA 125 Monoclonal Antibody, Purified (SIGNET)详细信息:
-
Description 
Purified Monoclonal Antibody against Cancer Antigen 125 (clone OC 125)
(Formerly Signet Catalog Nos: 617-01, 617-16 L1 Predilute, 617-26 L2 Predilute, 617-36 LV Predilute)Intended Use 
** In Vitro Diagnostic (IVD) ** Clone 
OC 125 Form 
Purified Antibody (in 0.01M PBS + 0.1% NaN3 + 1% BSA) Host 
Mouse Species Reactivity 
CA 125 Monoclonal Antibody, Purified (SIGNET)Human IsoType 
IgG1 Specificity 
This monoclonal antibody recognizes the CA 125 (Cancer Antigen 125) antigenic determinant which is present on a mucin-like glycoprotein of molecular weight greater than 200 kDa. OC 125 reacts with an antigen common to most non-mucinous epithelial ovarian carcinomas. It is positive in serous and endometrioid adenocarcinomas, Krukenberg’s tumor, and uterine myoma. Mucinous tumors (benign, borderline, malignant) and normal ovarian epithelium are negative. The CA 125 antigen is also detectable on the apical surface of normal endometrium and endocervix. Normal breast, skin, liver, spleen, and kidney are negative.
This antibody was generated against an ovarian cancer cell line OVCAR433 derived from a patient with serous papillary cystadenocarcinoma.
Concentrated Format:
SIG-3617-1000 [1 mL]
Prediluted Formats:
SIG-3617-16 [6 mL] is ready to use with Peroxidase Anti-Peroxidase detection systems.
SIG-3617-26 [6 mL] is ready-to-use with Biotin-based detection systems such as USA Ultra Streptavidin Detection (SIG-32250).
SIG-3617-36 [6 mL] is ready-to-use with Biotin based detection systems on Ventana ES and Ventana NexES automated immunostainers.Uses 
CA 125 Monoclonal Antibody, Purified (SIGNET)This antibody is effective in immunohistochemistry (IHC). Suggested Working Dilution 
The optimal working dilution should be determined for each specific assay condition. - IHC: ≥1:40 (concentrated format) for Biotin based detection systems such as USA Ultra Streptavidin Detection (SIG-32250).
Tissue Sections: Formalin-fixed, paraffin-embedded tissues
Pretreatment: For optimal staining, the sections should be pretreated with an antigen unmasking solution such as Retrieve-All 1 (SIG-31910).
Incubation: 60 minutes at room temperature
Notes 
Positive tissues (human): Non-mucinous epithelial ovarian carcinomas, serous and endometriod adenocarcinomas, Krukenberg’s tumor, and uterine myoma. Storage 
Store between 2-8°C. Warranty/Conditions 
Covance products may not be resold or modified for resale without prior written approval. - IHC: ≥1:40 (concentrated format) for Biotin based detection systems such as USA Ultra Streptavidin Detection (SIG-32250).
- CA 125 Monoclonal Antibody, Purified (SIGNET)
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CA 125 Monoclonal Antibody, Purified (SIGNET)
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