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Description | Purified Monoclonal Antibody against CD31 (PECAM-1) (Formerly Signet Catalog Nos: 632-01, 632-26 L2 Predilute) |
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Intended Use | **Research Use Only (RUO)** This product is sold for laboratory research use only, not for human or in-vivo use. |
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Clone | JC/70A | |
Form | Purified Antibody (in 0.01M PBS + 0.1% NaN3 + 1% BSA) | |
Host | Mouse | |
Species Reactivity | CD31 (JC/70A) Monoclonal Antibody, Purified (SIGNET)Human | |
IsoType | IgG1/kappa | |
Specificity | The Signet CD31 (JC/70A) antibody recognizes a 110 kDa glycoprotein in endothelial cells and a 130 kDa antigen in platelets. Clone JC/70A reacts with endothelial cells in normal and neoplastic tissues. In frozen sections and blood smears, the CD31 antibody also reacts with megakaryocytes, platelets and plasma cells. The CD31 antibody shows a weak reaction against mantle zone B cells, peripheral T cells and neutrophils. CD31 may also serve as a marker of angiogenesis. This antibody was generated using a spleen membrane preparation from a patient with hairy cell leukemia. Concentrated Format: SIG-3632-1000 [1 mL] Prediluted Format: SIG-3632-26 [6 mL] is ready-to-use with Biotin-based detection systems such as Signets USA Ultrastreptavidin Detection (SIG-32250). |
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Uses | CD31 (JC/70A) Monoclonal Antibody, Purified (SIGNET)This antibody is effective in immunohistochemistry (IHC). | |
Suggested Working Dilution | The optimal working dilution should be determined for each specific assay condition.
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Notes | Positive tissue (human): Skin, intestine, tonsil | |
Storage | Store between 2-8°C. | |
References | Charpin C, et al. CD31 quantitative immunocytochemical assays in breast carcinomas: correlation with current prognostic factors. Anatom Path 103(4):443-448, 1995. Parums DV, et al. JC70: a new monoclonal antibody that detects vascular endothelium associated antigen on routinely processed tissue sections. J Clin Pathol 43:752-757, 1990. |
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Warranty/Conditions | Covance products may not be resold or modified for resale without prior written approval. |
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