- ￥1525.01
- Biolegend
- made in USA
- 349509
- 2025年12月04日
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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 保存条件：
2-8°C
- 保质期：
1年
- 英文名：
APC anti-human CD81(TAPA-1)
- 库存：
100⁺盒
- 供应商：
上海睿安生物13611631389
- 规格：
25次/盒
Biolegend货号349509，APC anti-human CD81(TAPA-1)，(规格包装25次/盒)(目录价¥1525.00元/盒)13611631389上海睿安生物
Biolegend货号349509，APC anti-human CD81(TAPA-1)，(规格包装25次/盒)(目录价¥1525.00元/盒)13611631389上海睿安生物
DescriptionCD81 is a 26 kD non-glycosylated member of the tetraspanin superfamily (TM4SF), also known as TAPA-1 (target of an antiproliferative antibody). CD81 is expressed on T and B cells, NK cells, monocytes, dendritic cells, thymocytes, endothelial cells, and fibroblasts. It also has low levels of expression on granulocytes. CD81 induces B cell adhesion via VLA-4 integrin and has been shown to play a role in early T cell development. CD81 associates with several other cell-surface proteins in a multimolecular complex, including CD19, CD21, CD20, CD37, CD53, and CD82 in B cells, and CD4, CD8, and CD82 in T cells.
roduct Details
Isotype Control
APC Mouse IgG1, κ Isotype Ctrl (FC)
Verified Reactivity
Human
Reported Reactivity
African Green, Baboon, Cynomolgus, Rhesus
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human OCI-LY8 cell line
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Application
FC - Quality tested
Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Excitation Laser
Red Laser (633 nm)
Application Notes
Additional reported applications (for the relevant formats) include: Western Blotting3 and immunoprecipitation2,3.
Application References
(PubMed link indicates BioLegend citation)
Van Zelm MC, et al. 2010. J. Clin. Invest. 120:1265.
Oren R, et al. 1990. Mol. Cell. Biol. 8:4007. (IP)
Clark K, et al. 2004. J. Biol. Chem. 279(19):19401. (IP, WB)
Mochida K, et al. 2008. J. Virol. 13:6711.
Rappa G, et al. 2014. Mol Cancer Res. 12:1840. PubMed
Product Citations
Abe I, et al. 2022. Dev Cell. 57:2623. PubMed
Kocak P, et al. 2023. Aesthet Surg J Open Forum. 5:ojad039. PubMed
Ragni E, et al. 2021. Cells. 10: . PubMed
Ragni E, et al. 2022. Biomolecules. 12:. PubMed
Boruchowicz H, et al. 2020. J Virol. :94. PubMed
Ragni E, et al. 2022. Pharmaceutics. 14:. PubMed
Ragni E, et al. 2020. Stem Cell Res Ther. 165:11. PubMed
Oguri Y, et al. 2020. Cell. 182(3):563-577.e20. PubMed
Angeloni N, et al. 2016. Sci Rep. 6:22915. PubMed
Zimmerman B et al. 2016. Cell. 167(4):1041-1051 . PubMed
Najm FJ, et al. 2018. Nat Biotechnol. 36:179. PubMed
Samelson AJ, et al. 2022. Nat Cell Biol. 24:24. PubMed
See More
RRID
AB_2564020 (BioLegend Cat. No. 349509)
AB_2564021 (BioLegend Cat. No. 349510)
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- 作者
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文献和实验Biolegend货号349509，APC anti-human CD81(TAPA-1)，(规格包装25次/盒)(目录价¥1525.00元/盒)13611631389上海睿安生物
Biolegend货号349509，APC anti-human CD81(TAPA-1)，(规格包装25次/盒)(目录价¥1525.00元/盒)13611631389上海睿安生物
DescriptionCD81 is a 26 kD non-glycosylated member of the tetraspanin superfamily (TM4SF), also known as TAPA-1 (target of an antiproliferative antibody). CD81 is expressed on T and B cells, NK cells, monocytes, dendritic cells, thymocytes, endothelial cells, and fibroblasts. It also has low levels of expression on granulocytes. CD81 induces B cell adhesion via VLA-4 integrin and has been shown to play a role in early T cell development. CD81 associates with several other cell-surface proteins in a multimolecular complex, including CD19, CD21, CD20, CD37, CD53, and CD82 in B cells, and CD4, CD8, and CD82 in T cells.
roduct Details
Isotype Control
APC Mouse IgG1, κ Isotype Ctrl (FC)
Verified Reactivity
Human
Reported Reactivity
African Green, Baboon, Cynomolgus, Rhesus
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human OCI-LY8 cell line
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Application
FC - Quality tested
Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Excitation Laser
Red Laser (633 nm)
Application Notes
Additional reported applications (for the relevant formats) include: Western Blotting3 and immunoprecipitation2,3.
Application References
(PubMed link indicates BioLegend citation)
Van Zelm MC, et al. 2010. J. Clin. Invest. 120:1265.
Oren R, et al. 1990. Mol. Cell. Biol. 8:4007. (IP)
Clark K, et al. 2004. J. Biol. Chem. 279(19):19401. (IP, WB)
Mochida K, et al. 2008. J. Virol. 13:6711.
Rappa G, et al. 2014. Mol Cancer Res. 12:1840. PubMed
Product Citations
Abe I, et al. 2022. Dev Cell. 57:2623. PubMed
Kocak P, et al. 2023. Aesthet Surg J Open Forum. 5:ojad039. PubMed
Ragni E, et al. 2021. Cells. 10: . PubMed
Ragni E, et al. 2022. Biomolecules. 12:. PubMed
Boruchowicz H, et al. 2020. J Virol. :94. PubMed
Ragni E, et al. 2022. Pharmaceutics. 14:. PubMed
Ragni E, et al. 2020. Stem Cell Res Ther. 165:11. PubMed
Oguri Y, et al. 2020. Cell. 182(3):563-577.e20. PubMed
Angeloni N, et al. 2016. Sci Rep. 6:22915. PubMed
Zimmerman B et al. 2016. Cell. 167(4):1041-1051 . PubMed
Najm FJ, et al. 2018. Nat Biotechnol. 36:179. PubMed
Samelson AJ, et al. 2022. Nat Cell Biol. 24:24. PubMed
See More
RRID
AB_2564020 (BioLegend Cat. No. 349509)
AB_2564021 (BioLegend Cat. No. 349510)
CD81 分子 CD81 常用单克隆抗体或代号： ID6,5A6;(TAPA- 1) 主要表达细胞： 广泛,包括B,T,M [B] 分子质量(kDa)和结构： p26(TM4-SF) 功 能： 增殖抗体靶抗原,与CD19、CD21相连,组成B细胞复合体 CD81 Aka Target of an Anti-Proliferative Antibody (TAPA1)
磷酸化，参与启动信号转导。敲除CDl9基因小鼠不仅对TD抗原应答受损，且无生发中心生成，也无抗体亲和力成熟。 (3)CDSl：属四次跨膜蛋白超家族(TM4-SF)成员。因抗CD81单抗有显著抑制淋巴细胞增殖作用，又名TAPA-1(targetO{anti-proliferativeantibody)。 (4)其他辅佐分子 CD45：又称白细胞共同抗原(LCA)。为单链I型跨膜蛋白。胞内部分由两个结构域组成，属蛋白酪氨酸磷酸酶(PTP)，参与启动B细胞抗原识别信号的转导
三句话读懂一篇 CNS，鸟类迁移的秘密揭晓，绿色中药助力肥胖治疗，突破血脑屏障的递送技术...
humanization comes to the rescue of circulating human red blood cells。该工作将小鼠肝脏替换为人肝脏，发现人的红细胞在人源化小鼠体内正常生长发育，成熟的红细胞能够在小鼠体内循环，进而使得人的血液流淌。该新型人源化小鼠研究工具可用于造血干细胞疾病、红细胞和肝脏生理学联系研究，为临床药物的筛选鉴定开辟新途径。 图 1：来源 Science 2. Cell Metabolism: 高纤维膳食预防肥胖孕妇对后代认知及行为的伤害 动物和人体研究数据表明，孕妇
