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Ubiquitin Polyclonal Antibody

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  • ATCC
  • 美国/中国
  • xy-268C
  • 2025年07月14日
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    上海信裕生物科技有限公司
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    • 保存条件：

      4℃保存

    • 保质期：

      6个月

    • 英文名：

      Ubiquitin Polyclonal Antibody

    • 库存：

      1

    • 供应商：

      上海信裕

    • Ubiquitin Polyclonal Antibody保存于运输说明：
    • Store at -20°C
    • 详细信息：
    • Description Ubiquitin Polyclonal Antibody - NEUROSCIENCE Polyclonal Antibody against Ubiquitin
      Form 产品细节图片1 Antiserum
      Host 产品细节图片2 Rabbit
      Species Reactivity 产品细节图片3 Ubiquitin Polyclonal Antibody Human
      Specificity Ubiquitin Polyclonal Antibody - NEUROSCIENCE Ubiquitin is a highly conserved globular 76 amino acid protein of about 8.5 kDa molecular weight. It has a important role in the targeting of proteins for proteolytic degradation. Proteins to be degraded are covalantly coupled to the C-terminus of ubiquitin by means of ubiquitin ligases. The ubiquitin itself is frequently also ubiquitinated, producing a polyubiquitin chain. The polyubquitinated complex is then recognized by a complex of degradative enzymes which together form the proteosome. Interestingly, ubiquitin also becomes covalently bonded to many types of pathological inclusions seen in serious human disease states which appear to be resistant to normal degradation, so that ubiquitin antibodies are very useful for studies of these inclusions. For example the neurofibrillary tangles and paired helical filaments diagnostic of Alzheimers disease, the Lewy bodies seen in Parkinsons disease, and Pick bodies found in Picks disease are all heavily ubiquitinated and can all be readily visualized with ubiquitin antibodies of appropriate specificity. Ubiquitin antibodies have become very widely used for such studies.

      This antibody was raised against glutaraldehyde cross linked ubiquitin.
      Uses Ubiquitin Polyclonal Antibody - NEUROSCIENCE Ubiquitin Polyclonal Antibody This antiserum is effective in immunoblotting (WB) and immunofluorescence (IF).
      Suggested Working Dilution Ubiquitin Polyclonal Antibody - NEUROSCIENCE The optimal working dilution should be determined for each specific assay condition. This antibody is sold for laboratory research use only, not for human or in-vivo use. Covance antibodies may not be resold or modified for resale without prior written approval.
      • WB: 1:5,000-10,000*
      • IF: 1:500-1,000
      Notes Ubiquitin Polyclonal Antibody - NEUROSCIENCE *Predicted MW = 8.5kD
      Storage Ubiquitin Polyclonal Antibody - NEUROSCIENCE Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. For long-term storage, keep the antibody at -80°C.
      Warranty/Conditions Ubiquitin Polyclonal Antibody - NEUROSCIENCE Covance products may not be resold or modified for resale without prior written approval.
      Rev. Date Ubiquitin Polyclonal Antibody - NEUROSCIENCE 11/8/2006 Ubiquitin Polyclonal Antibody
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