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- 详细信息
- 技术资料
- 保存条件：
4℃保存
- 保质期：
6个月
- 英文名：
UBE1L C-Terminal Polyclonal Antibody
- 库存：
1
- 供应商：
上海信裕
- UBE1L C-Terminal Polyclonal Antibody保存于运输说明：
- Store at -20°C.
- 详细信息：
-
Description 
Polyclonal Antibody against Ubiquitin Activating Enzyme E1-Like (UBE1L) C-Terminal Form Antiserum Host UBE1L C-Terminal Polyclonal Antibody Rabbit Species Reactivity Human Specificity UBE1L has high sequence identity with the ubiquitin-activating enzyme UBE1 and has been identified as the activating enzyme for the ubiquitin-like protein interferon stimulated gene 15 kDa (ISG15) . UBE1L is readily induced in acute promyelocytic leukemia (APL) by the chemotherapeutic agent all-trans-retinoic acid. Over-expression of UBE1L caused APL cell death and degradation of the oncogenic protein promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARα). UBE1L has also been implicated in potentiating interferon signaling and is a potential lung cancer tumor suppressor as UBE1L expression is repressed in lung cancer cell lines. Recent work has detected UBE1L protein in normal human lung epithelium. Anti-UBE1L antibodies would be valuable reagents in determining whether UBE1L is a tumor suppressor protein and further investigating the role of UBE1L in ISG15 conjugation and cellular signaling pathways. Uses UBE1L C-Terminal Polyclonal Antibody This antibody is effective in immunoblotting. Suggested Working Dilution The optimal working dilution should be determined for each specific assay condition. This antibody is sold for laboratory research use only, not for human or in-vivo use. Covance antibodies may not be resold or modified for resale without prior written approval. - Western blot: 1:1,000*
Notes *Predicted MW = 112kD Storage Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. For long-term storage, keep the antibody at -80°C. References Malakhova OA, Yan M, Malakhov MP, Yuan Y, Ritchie KJ, Kim KI, Peterson LF, Shuai K, Zhang DE. Protein ISGylation modulates the JAK-STAT signaling pathway. Genes Dev. 17(4):455-60, 2003.
Kitareewan S, Pitha-Rowe I, Sekula D, Lowrey CH, Nemeth MJ, Golub TR, Freemantle SJ, Dmitrovsky E. UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia. Proc. Natl. Acad. Sci. USA 99(6):3806-11, 2002.
Yuan W, Krug RM. Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein. EMBO. J. 20(3):362-71, 2001.
McLaughlin PM, Helfrich W, Kok K, Mulder M, Hu SW, Brinker MG, Ruiters MH, de Leij LF, Buys CH. The ubiquitin-activating enzyme E1-like protein in lung cancer cell lines. Int. J. Cancer 85(6):871-6, 2000.Warranty/Conditions Covance products may not be resold or modified for resale without prior written approval. - UBE1L C-Terminal Polyclonal Antibody
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UBE1L C-Terminal Polyclonal Antibody
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