Chemical Name: 2-[2-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-3-methoxy-2H-pyrrol-5- yl ]-1H-indole mesylate
Appearance: Dark purple powder
Solubility: Soluble in DMSO (50 mg/ml), slightly soluble in water.
Storage:Store powder at -20 ºC for the stability of three years
储存液配制
储存液 (1 ml DMSO)
1 mM
5 mM
10 mM
25 mM
50 mM
质量(mg)
0.4135
2.0675
4.1349
10.3373
20.6745
Obatoclax Mesylate(Bcl-2 Family Inhibitor) Structure
参考文献
[1] Zhai D, et al. Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins. Cell Death Differ. 13(8):1419-21 (2006).
[2] Nguyen M, et al. Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis.Proc Natl Acad Sci U S A. 104(49):19512-7 (2007).
[3] Konopleva M, et al. Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax).Cancer Res. 68(9):3413-20 (2008).
[4] Trudel S, et al. Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma. Blood. 109(12):5430-8 (2007).