Garcinol

Garcinol产品描述

Garcinol（Camboginol）是组蛋白乙酰转移酶P300和PCAF的抑制剂，其IC₅₀分别7μM和5μM ^[1]。Garcinol也抑制新型隐球菌的HAT GCN5，诱导其温度敏感性和影响生长^[2]。Garcinol（从藤黄籼中分离）能促进人造血干细胞神经元的再生和体外扩增^[3,4]。而且Garcinol诱导几种类型癌细胞的凋亡并具有抗炎作用^[5,6]。

靶点

Garcinol化学特性

储存液配制

Garcinol结构式

参考文献

[1] Balasubramanyam K, et al. Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression. J Biol Chem. 279(32):33716-26(2004).

[2] OMeara TR, et al. Cryptococcus neoformans histone acetyltransferase Gcn5 regulates fungal adaptation to the host. Eukaryot Cell. 9(8):1193-202. (2010).

[3] Weng MS, et al. Garcinol promotes neurogenesis in rat cortical progenitor cells through the duration of extracellular signal-regulated kinase signaling. J Agric Food Chem. 59(3):1031-40(2011).

[4] Nishino T, et al. Ex vivo expansion of human hematopoietic stem cells by garcinol, a potent inhibitor of histone acetyltransferase. PLoS One. 6(9):e24298. (2011).

[5] Prasad S, et al. Garcinol potentiates TRAIL-induced apoptosis through modulation of death receptors and antiapoptotic proteins. Mol Cancer Ther. 9(4):856-68(2010).

[6] Koeberle A, et al. Identification of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 as functional targets of the anti-inflammatory and anti-carcinogenic garcinol. Biochem Pharmacol. 77(9):1513-21(2009).

Garcinol
xy-10050M IBDV鸡传染性法氏囊病病毒抗体
xy-4749R Integrin beta 6整合素β6/Integrin β6抗体
xy-11256R INPP5F磷酸肌醇磷酸酶蛋白INPP5抗体
xy-6841R IL-4I1白细胞介素4诱导蛋白1抗体
xy-6840R IEX1分化相关基因2蛋白/立即早期反应蛋白抗体
xy-7637R ICAM4细胞间粘附分子4抗体
xy-9633R ITFG3整联蛋白重复蛋白3抗体
xy-8683R IGF2BP1胰岛素样生长因子ⅡmRNA结合蛋白1抗体
xy-8559R IGF2BP2胰岛素样生长因子ⅡmRNA结合蛋白2抗体
xy-4847R phospho-ITGB4(Tyr1530)磷酸化整合素β4抗体
xy-1822R IGFBP1胰岛素样生长因子结合蛋白1抗体
xy-1823R IGFBP4/IBP4胰岛素样生长因子结合蛋白4抗体
xy-1816R ITGA7整合素α7抗体
xy-1811R IL-7白介素7抗体
xy-1805R IL-6R alpha白细胞介素6受体α/IL-6Rα抗体
xy-2428R IL-9白介素9抗体
xy-1804R Integrin alpha L整合素αL抗体Integrin αL
xy-1578R Interferon alpha干扰素α抗体
xy-3402R Phospho-INPPL1(Ser576)磷酸化肌醇聚磷酸盐磷酸酶样蛋白1抗体
xy-3404R Phospho-INPPL1(Tyr986 + Tyr987)磷酸化肌醇聚磷酸盐磷酸酶样蛋白1抗体
xy-1826R Inhibin Beta C抑制素βC抗体
xy-1830R IL-16白介素16抗体
xy-1825R Inhibin beta B抑制素βB/Inhibin β B抗体
xy-1827R IL-11白介素11抗体
xy-2624R IL-22R白介素22受体抗体
xy-2626R IL-26/AK155白介素26抗体
xy-2612R IL-17D/IL-27白介素-17D抗体
xy-15531R IBRDC1环指蛋白217抗体
xy-0605R IL-2白介素2抗体(人)
xy-1460R IL-23R白介素-23受体抗体
xy-1434R IGFBP3胰岛素样生长因子结合蛋白3抗体
xy-1459R IL-6R Beta/CD130/gp130白细胞介素6受体β抗体IL-6Rβ
xy-1463R IFNGR1干扰素-gamma受体1抗体
xy-10540R IL-1 Alpha Propeptide白介素1α前肽/IL-1α前肽抗体