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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 保存条件：
-20°C
- 保质期：
1年
- 英文名：
Collagenase IV(Type IV)
- 库存：
100⁺瓶
- 供应商：
上海睿安生物13611631389
- 规格：
1g/瓶
Collagenase IV胶原酶IV型Sigma货号V900893-1g胶原酶 来源于溶组织梭菌(Type IV)上海睿安生物13611631389
Collagenase IV胶原酶IV型Sigma-Aldrich货号V900893-1g胶原酶 来源于溶组织梭菌(Type IV)上海睿安生物13611631389
说明
一般描述:来自溶组织梭菌(Clostridium histolyticum)的胶原酶是一种胶原分解酶。它与胶原蛋白样物质相互作用，将胶原蛋白降解成小分子肽。
应用
来自溶组织梭菌(Clostridium histolyticum)的胶原酶，可用于从许多类型的动物组织中分离细胞。VETEC IV型胶原酶具有较低的胰蛋白酶活性。它适用于消化胰腺中的胰岛细胞。
适用于制备用于测序的单细胞悬浮液。
适用于制备用于测序的单细胞悬浮液。
生化/生理作用:每摩尔胶原蛋白酶被4g原子钙活化。 它被乙二醇-双(β-氨基乙基醚)-N，NN′,N′-四乙酸，β-巯基乙醇、谷胱甘肽、巯_基乙酸和8-羟基喹_啉抑制。
质量:还含有梭菌蛋白酶、中性蛋白酶和胰蛋白酶活性。
单位定义
一个胶原蛋白消化单元(CDU)从牛跟腱胶原蛋白中释放的肽链量和1.0μ亮氨酸，5小时，pH7.4,37℃，在钙离子存在下的茚三酮颜色相同。一个FALGPA水解单元每分钟，25℃，水解1.0μmole呋喃基丙烯酰-Leu-Gly-Pro-Ala。一个中性蛋白酶单元水解酪蛋白，产生颜色和1.0μmole 酪氨酸每5小时，pH7.5,37℃下产生的相同。一个梭菌蛋白酶单元在DTT存在下，pH7.6,25℃，每分钟水解1.0μmole BAEE。
同行评审论文
Single-cell analysis reveals immune modulation and metabolic switch in tumor-draining lymph nodes.
Yen-Liang Li et al.
Oncoimmunology, 9(1), 1830513-1830513 (2020-10-30)
Lymph-node metastasis is a prognosis factor for poor clinical outcome of breast cancer patients. Currently, how breast cancer cells establish pre-metastatic niche in the tumor-draining lymph nodes (TDLNs) is still unclear. To address this question, we isolated heterogeneous cells including
Reversibility of experimental rabbit liver cirrhosis by portal collagenase administration.
Jin B, et al.
Laboratory Investigation; a Journal of Technical Methods and Pathology, 85(8), 992-992 (2005)
Telomerase reverse transcriptase acts in a feedback loop with NF-KB pathway to regulate macrophage polarization in alcoholic liver disease.
Wu X Q, et al.
Scientific Reports, 6, 18685-18685 (2016)
Telomerase reverse transcriptase acts in a feedback loop with NF-κB pathway to regulate macrophage polarization in alcoholic liver disease.
Xiao-Qin Wu et al.
Scientific reports, 6, 18685-18685 (2016-01-05)
Activation of Kupffer cells (KCs) plays a central role in the pathogenesis of alcoholic liver disease (ALD). C57BL/6 mice fed EtOH-containing diet showed a mixed induction of hepatic classical (M1) and alternative (M2) macrophage markers. Since telomerase activation occurs at
4-Methylcoumarin-[5,6-g]-hesperetin attenuates inflammatory responses in alcoholic hepatitis through PPAR-γ activation.
Hong-Wu Meng et al.
Toxicology, 421, 9-21 (2019-04-06)
4-Methylcoumarin-[5,6-g]-hesperetin (4-MCH) is a hesperidin derivative produced by the structural modification of hesperetin. Alcoholic hepatitis (AH) is the origin of many serious liver diseases that are accompanied by hepatic inflammation. In this study, we detected the anti-inflammatory activity of 4-MCH
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文献和实验该产品被引用文献
Collagenase IV胶原酶IV型Sigma货号V900893-1g胶原酶 来源于溶组织梭菌(Type IV)上海睿安生物13611631389
Collagenase IV胶原酶IV型Sigma-Aldrich货号V900893-1g胶原酶 来源于溶组织梭菌(Type IV)上海睿安生物13611631389
说明
一般描述:来自溶组织梭菌(Clostridium histolyticum)的胶原酶是一种胶原分解酶。它与胶原蛋白样物质相互作用，将胶原蛋白降解成小分子肽。
应用
来自溶组织梭菌(Clostridium histolyticum)的胶原酶，可用于从许多类型的动物组织中分离细胞。VETEC IV型胶原酶具有较低的胰蛋白酶活性。它适用于消化胰腺中的胰岛细胞。
适用于制备用于测序的单细胞悬浮液。
适用于制备用于测序的单细胞悬浮液。
生化/生理作用:每摩尔胶原蛋白酶被4g原子钙活化。 它被乙二醇-双(β-氨基乙基醚)-N，NN′,N′-四乙酸，β-巯基乙醇、谷胱甘肽、巯_基乙酸和8-羟基喹_啉抑制。
质量:还含有梭菌蛋白酶、中性蛋白酶和胰蛋白酶活性。
单位定义
一个胶原蛋白消化单元(CDU)从牛跟腱胶原蛋白中释放的肽链量和1.0μ亮氨酸，5小时，pH7.4,37℃，在钙离子存在下的茚三酮颜色相同。一个FALGPA水解单元每分钟，25℃，水解1.0μmole呋喃基丙烯酰-Leu-Gly-Pro-Ala。一个中性蛋白酶单元水解酪蛋白，产生颜色和1.0μmole 酪氨酸每5小时，pH7.5,37℃下产生的相同。一个梭菌蛋白酶单元在DTT存在下，pH7.6,25℃，每分钟水解1.0μmole BAEE。
同行评审论文
Single-cell analysis reveals immune modulation and metabolic switch in tumor-draining lymph nodes.
Yen-Liang Li et al.
Oncoimmunology, 9(1), 1830513-1830513 (2020-10-30)
Lymph-node metastasis is a prognosis factor for poor clinical outcome of breast cancer patients. Currently, how breast cancer cells establish pre-metastatic niche in the tumor-draining lymph nodes (TDLNs) is still unclear. To address this question, we isolated heterogeneous cells including
Reversibility of experimental rabbit liver cirrhosis by portal collagenase administration.
Jin B, et al.
Laboratory Investigation; a Journal of Technical Methods and Pathology, 85(8), 992-992 (2005)
Telomerase reverse transcriptase acts in a feedback loop with NF-KB pathway to regulate macrophage polarization in alcoholic liver disease.
Wu X Q, et al.
Scientific Reports, 6, 18685-18685 (2016)
Telomerase reverse transcriptase acts in a feedback loop with NF-κB pathway to regulate macrophage polarization in alcoholic liver disease.
Xiao-Qin Wu et al.
Scientific reports, 6, 18685-18685 (2016-01-05)
Activation of Kupffer cells (KCs) plays a central role in the pathogenesis of alcoholic liver disease (ALD). C57BL/6 mice fed EtOH-containing diet showed a mixed induction of hepatic classical (M1) and alternative (M2) macrophage markers. Since telomerase activation occurs at
4-Methylcoumarin-[5,6-g]-hesperetin attenuates inflammatory responses in alcoholic hepatitis through PPAR-γ activation.
Hong-Wu Meng et al.
Toxicology, 421, 9-21 (2019-04-06)
4-Methylcoumarin-[5,6-g]-hesperetin (4-MCH) is a hesperidin derivative produced by the structural modification of hesperetin. Alcoholic hepatitis (AH) is the origin of many serious liver diseases that are accompanied by hepatic inflammation. In this study, we detected the anti-inflammatory activity of 4-MCH
相关实验
气坏疽菌——韦氏梭菌在培养滤液中产生的一种毒蛋白。它具有蛋白酶的作用，可分解胶原蛋白和白明胶等，但不能分解卵清蛋白和血清蛋白。能对脯氨酸-X-甘氨酸 -脯氨酸 -Y这样结构的甘氨酸和脯氨酸间的结合键水解。 EC3． 4． 24． 3．
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Collagenase IV胶原酶IV型Sigma货号V900893-1g上海睿安生物13611631389
￥2623.86
