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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
-20℃
- 克隆性:
单克隆
- 抗体名:
YY1 Transcription Factor (YY1) (N-Term) 抗体
- 规格:
0.1ml/0.2ml
YY1 Transcription Factor (YY1)
别名
yy1-a, FIII, MGC83714, yy1l, zgc:64207, YY1, LOC494431, xyy1, delta, nf-e1, ucrbp, yin-yang-1, LOC100304682, ino80s, yy1, DELTA, INO80S, NF-E1, UCRBP, YIN-YANG-1, AW488674, fb59g10, wu:fa16g07, wu:fb5 ... show more
抗原表位
其他选择 N-Term
适用
其他选择 小鼠, 大鼠, 犬, 牛, 非洲爪蟾, 人, 斑马鱼, 小鸡
宿主
其他选择 兔
克隆类型
多克隆
标记
其他选择 非结合性
应用范围
其他选择 Western Blotting (WB)
Pubmed 找到1个引用
规格 50 μg
发货至 中国 (更改)
发货时间 9至12个工作日
产品编号 yb183635
产品细节 YY1 Transcription Factor (YY1) (N-Term) 抗体
免疫原 Synthetic peptide directed towards the N terminal of human YY1
序列 MASGDTLYIA TDGSEMPAEI VELHEIEVET IPVETIETTV VGEEEEEDDD
预测反应 African clawed frog : 100 %, Bovine : 100 %, Chicken : 100 %, Dog : 100 %, Human : 100 %, Mouse : 100 %, Rat : 100 %, Zebrafish : 100 %
产品特性 This is a rabbit polyclonal antibody against YY1. It was validated on Western Blot using a cell lysate as a positive control.
纯化方法 Affinity Purified
目标详细情况 YY1 Transcription Factor (YY1) (N-Term) 抗体
别名 YY1
背景 YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1.YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1.
分子量 45 kDa
基因ID 7528
NCBI登录号 NP_003394, NM_003403
UniProt P25490
使用细节YY1 Transcription Factor (YY1) (N-Term) 抗体
应用备注 Optimal working dilutions should be determined experimentally by the investigator.
说明
Antigen size: 414 AA
限制 仅限研究用
贮存及处理 YY1 Transcription Factor (YY1) (N-Term) 抗体
状态 Lyophilized
溶解方式 Add 50 µL of distilled water.
浓度 1 mg/mL
缓冲液 PBS buffer with 2 % sucrose
注意事项 Avoid repeated freeze-thaw cycles.
储存条件 -20 °C
储存方法 For longer periods of storage, store at -20 °C
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文献和实验9.23 上交复旦Science子刊揭示靶向YY1有望治疗糖尿病肾病
① 上交复旦Science 子刊揭示靶向 YY1 有望治疗糖尿病肾病转化生长因子β1(TGFβ1,由基因 TGFB1 编码)已被确定为糖尿病肾病产生的主要致病因子。然而,当前的拮抗 TGFβ1 的策略未能在临床试验中表现出有益的治疗结果。在一项新的研究中,来自中国上海交通大学和复旦大学等研究机构的研究人员为了鉴定出一种不同的治疗方法,设计出一种基于质谱的 DNA-蛋白相互作用筛选方法,以便发现与 TGFβ1 启动子结合的转录阻遏物。他们鉴定出一种称为阴阳 1(Yin Yang 1, YY1
Using Weeder for the Discovery of Conserved Transcription Factor Binding Sites
, W., Rouchka, E.C., and Lawrence, C.E. 2003. Gibbs Recursive Sampler: Finding transcription factor binding sites. Nucl. Acids Res. 31:3580‐3585. Tompa, M., Li, N., Bailey
of short peptide tags that are efficiently biotinylated by the bacterial BirA biotin ligase led to an approach for the singlestep purification of transcription factor complexes by specific in vivo biotinylation tagging. A short sequence tag fused N
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