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- 详细信息
- 技术资料
- 克隆性：
单克隆
- 抗体英文名：
Anti-Ku70(ATP depend
- 抗体名：
DNA修复酶Ku70抗体
DNA修复酶Ku70抗体产品标准
浓缩液(1mg/1ml) 亲和纯化抗体
产品应用
WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 （石蜡切片需做抗原修复）
DNA修复酶Ku70抗体产品介绍
Ku-70是一种DNA修复蛋白，当细胞在受到辐射损伤而发生DNA双链断裂时，Ku70可迅速将其修复，从而提高细胞存活率.
Ku是一种多功能的蛋白，在许多重要的细胞生命过程中起着直接或间接的作用，如DNA双链断裂的修复，免疫球蛋白和T细胞受体V（D）J重排，免疫球蛋白构型转换，DNA复制，DNA转录的调节，同时在细胞周期的G2和M时相中起着特殊的作用.
The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq].
Ku70 heterodimerises with Ku80 to form the ATP-dependent DNA helicase II, a single stranded helicase that binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. The heterodimer plays a role in non-homologous end-joining (NHEJ) required for double-strand break repair and V(D)J recombination. It acts as the regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit (PRKDC) for DNA. The Ku70/80 heterodimer is also required for osteocalcin gene expression.
mol wt:61-69kDa
Other Aliases:
70 kDa subunit of Ku antigen; 70 kDa subunit of Ku antigen; ATP dependent DNA helicase 2 subunit 1; ATP dependent DNA helicase II 70 kDa subunit; CTC box binding factor 75 kDa subunit; CTC75; CTCBF; DNA repair protein XRCC6; G22P1; Ku 70; Ku autoantigen 70kDa; Ku autoantigen p70 subunit; Ku autoantigen, 70kDa; Ku p70; Ku70 DNA binding component of DNA-dependent proteinkinase complex (thyroid autoantigen 70 kDa; Kup70; Lupus Ku autoantigen protein p70; ML8; Thyroid autoantigen 70kD (Ku antigen); Thyroid autoantigen; Thyroid lupus autoantigen; Thyroid lupus autoantigen p70; TLAA; X ray repair complementing defective repair in Chinese hamster cells 6; XRCC 6; XRCC6
Ku是一种多功能的蛋白，在许多重要的细胞生命过程中起着直接或间接的作用，如DNA双链断裂的修复，免疫球蛋白和T细胞受体V（D）J重排，免疫球蛋白构型转换，DNA复制，DNA转录的调节，同时在细胞周期的G2和M时相中起着特殊的作用.
The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq].
Ku70 heterodimerises with Ku80 to form the ATP-dependent DNA helicase II, a single stranded helicase that binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. The heterodimer plays a role in non-homologous end-joining (NHEJ) required for double-strand break repair and V(D)J recombination. It acts as the regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit (PRKDC) for DNA. The Ku70/80 heterodimer is also required for osteocalcin gene expression.
mol wt:61-69kDa
Other Aliases:
70 kDa subunit of Ku antigen; 70 kDa subunit of Ku antigen; ATP dependent DNA helicase 2 subunit 1; ATP dependent DNA helicase II 70 kDa subunit; CTC box binding factor 75 kDa subunit; CTC75; CTCBF; DNA repair protein XRCC6; G22P1; Ku 70; Ku autoantigen 70kDa; Ku autoantigen p70 subunit; Ku autoantigen, 70kDa; Ku p70; Ku70 DNA binding component of DNA-dependent proteinkinase complex (thyroid autoantigen 70 kDa; Kup70; Lupus Ku autoantigen protein p70; ML8; Thyroid autoantigen 70kD (Ku antigen); Thyroid autoantigen; Thyroid lupus autoantigen; Thyroid lupus autoantigen p70; TLAA; X ray repair complementing defective repair in Chinese hamster cells 6; XRCC 6; XRCC6
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yb-3255R Phospho-Lck (Tyr505)磷酸化淋巴细胞特异性蛋白酪氨酸激酶抗体
yb-2906R Lyn膜相关蛋白酪氨酸激酶Lyn抗体
yb-3256R Phospho-Lyn (Tyr507)磷酸化膜相关蛋白酪氨酸激酶Lyn抗体
yb-3257R Phospho-Lyn (Tyr397)磷酸化膜相关蛋白酪氨酸激酶Lyn抗体
yb-1974R LRRC4脑瘤相关基因抗体
yb-11091R LSAMP大脑边缘系统相关膜蛋白抗体
yb-11087R LRFN2神经突触粘附样分子1抗体
yb-11089R LRFN4富含亮氨酸重复序列/Ⅲ型纤维连接蛋白4抗体
yb-11056R Laminin alpha 4层粘蛋白α4抗体(Lamininα4)
yb-11055R Laminin alpha 4层粘蛋白α4抗体(Lamininα4)
yb-11286R lipocalin 1脂质运载蛋白1抗体
yb-11287R Lymphotactin淋巴细胞趋化因子抗体
yb-11590R LRP5L低密度脂蛋白受体5样蛋白抗体
yb-11571R LRRTM3富含亮氨酸重复跨膜神经元蛋白3抗体
yb-6439R Lens culinaris agglutinin扁豆凝集素
yb-11786R phospho-LRRK2(Thr1410)磷酸化富亮氨酸重复激酶2抗体
yb-0961M Leptin receptor瘦素受体抗体
yb-11057R Elastin项韧带弹性蛋白抗体
yb-8574R ox-LDL氧化低密度脂蛋白抗体
yb-5779R LTBP4转化生长因子β结合蛋白4抗体
yb-5765R LANCL2G蛋白偶联受体69B
yb-4581R Listeria tropina李斯特菌菌体蛋白抗体
yb-4213R LARGRho的鸟嘌呤核苷酸交换因子12抗体
yb-6395R LEU5白血病相关蛋白5抗体
yb-7809R LRRC62富含亮氨酸重复蛋白62抗体
yb-6963R LPAP淋巴细胞磷蛋白磷酸酶相关蛋白抗体
yb-8303R LGI4含亮氨酸神经胶质瘤失活蛋白4抗体
yb-8305R LYL1淋巴细胞性白血病相关序列1抗体
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DNA修复酶Ku70抗体
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