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- 钰博生物
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- 2025年12月06日
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- 克隆性：
单克隆
- 抗体英文名：
Anti-MMP-11(matrix m
- 抗体名：
北京博奥森生物技术有限公司
北京博奥森生物技术有限公司产品标准
浓缩液(1mg/1ml) 亲和纯化抗体
产品应用
WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 （石蜡切片需做抗原修复）
北京博奥森生物技术有限公司产品介绍
MMP-11主要用于肿瘤方面的研究。
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1 proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. MMP11, also known as stromelysin 3, is overexpressed in the stromal cells of invasive breast carcinomas but not in the stromal cells surrounding benign breast fibroadenomas. MMP11 is secreted in its proenzyme from and the zymogen has a mass of 64 kDa. The enzyme is rapidly activated to a 58 kDa form, a 45-47 kDa size, then to a 28 kDa final active form. MMP11 is not constitutively produced by most cell types. It has been found in lung fibroblasts and gingival fibroblasts when stimulated with EGF, as well as breast tumor and osteocarcinoma cell lines.
mol wt:55kDa
Other Aliases:
matrix metalloproteinase 11; Stromelysin-3; SL-3; Short=ST3; Matrix metalloproteinase-11
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1 proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. MMP11, also known as stromelysin 3, is overexpressed in the stromal cells of invasive breast carcinomas but not in the stromal cells surrounding benign breast fibroadenomas. MMP11 is secreted in its proenzyme from and the zymogen has a mass of 64 kDa. The enzyme is rapidly activated to a 58 kDa form, a 45-47 kDa size, then to a 28 kDa final active form. MMP11 is not constitutively produced by most cell types. It has been found in lung fibroblasts and gingival fibroblasts when stimulated with EGF, as well as breast tumor and osteocarcinoma cell lines.
mol wt:55kDa
Other Aliases:
matrix metalloproteinase 11; Stromelysin-3; SL-3; Short=ST3; Matrix metalloproteinase-11
北京博奥森生物技术有限公司
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