MMP-11主要用于肿瘤方面的研究。
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1 proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. MMP11, also known as stromelysin 3, is overexpressed in the stromal cells of invasive breast carcinomas but not in the stromal cells surrounding benign breast fibroadenomas. MMP11 is secreted in its proenzyme from and the zymogen has a mass of 64 kDa. The enzyme is rapidly activated to a 58 kDa form, a 45-47 kDa size, then to a 28 kDa final active form. MMP11 is not constitutively produced by most cell types. It has been found in lung fibroblasts and gingival fibroblasts when stimulated with EGF, as well as breast tumor and osteocarcinoma cell lines.xy-15472R HGD尿黑酸氧化酶抗体
xy-15473R HGS 肝细胞生长调节因子酪氨酸激酶底物抗体
xy-15474R HHATT细胞2识别黑色素瘤抗原抗体
xy-15475R HHCM肝细胞癌HHCM蛋白抗体
xy-15481R hHR23A紫外切除修复蛋白RAD23A抗体
xy-15482R hHR23b紫外切除修复蛋白RAD23B抗体
xy-15483R HIBADH3-羟基异丁酸脱氢酶抗体
xy-15484R HIBCH Hib乙酰辅酶A水解酶抗体
xy-15485R HIC1肿瘤异常甲基化蛋白1抗体
xy-15486R HIC2 肿瘤异常甲基化蛋白2抗体
xy-15487R HIF Prolyl Hydroxylases缺氧诱导因子脯氨酰羟化酶4抗体
xy-15466R HERV-FRD 人内源性逆转录病毒膜糖蛋白2抗体
xy-15468R HEXB chain BBeta氨基己糖苷酶beta亚基蛋白B链抗体
xy-15469R HEXIM2HEXIM2蛋白抗体
xy-15470R HEXO3'-5'外切酶1蛋白抗体
xy-15451R Hepatitis C virus NS5B丙型肝炎病毒NS5B抗体
xy-15490R HIGD1C缺氧诱导基因1C蛋白抗体
xy-15449R HEG1HEG同源蛋白1抗体
xy-15450R HELZ人肿瘤抑制蛋白抗体
xy-15452R HEMK1Hemk甲基转移酶家族1号蛋白抗体
xy-15453R HEMK2Hemk甲基转移酶家族2号蛋白抗体
xy-15454R HENMT1HEN1甲基转移酶同源蛋白1抗体
xy-15488R HIG2缺氧诱导基因2蛋白抗体
xy-15455R HBcAg乙肝病毒衣壳蛋白抗体
xy-15456R Hepatitis C Virus genotype 1a NS5 丙型肝炎病毒1a基因型NS5蛋白抗体
xy-15457R HEV Capsid protein戊型肝炎病毒抗体
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