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    病毒包装服务/病毒包装检测/病毒载体构建
    • ¥2000 - 10000
    • 提供载体构建、腺相关病毒、慢病毒、腺病毒、逆转录病毒包装服务
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      • 提供商:

        和元上海

      • 服务名称:

        病毒包装服务/病毒包装检测/病毒载体

      • 规格:

        1.0E+8~1.0E+12

            和元上海提供腺相关病毒(AAV)、慢病毒(LV)、腺病毒(ADV)、逆转录病毒(RV)包装服务。这几种病毒的生产和质控采取了国际学术界公认的标准流程,所获得的病毒完全可以满足各类实验的使用要求:
             腺相关病毒AAV(和元)的滴度在1012~1013v.g./ml
             慢病毒(和元)的滴度在10
      8~109TU/ml
             腺病毒(和元)的滴度在1010~1011pfu/ml
             逆转录病毒(和元)滴度在107~108TU/ml
             和元上海的技术团队拥有十年以上的病毒载体开发和病毒包装服务经验。我们依靠坚持不懈的努力和精益求精的态度,推动了病毒载体在国内的技术转化和应用推广。
             随着生物医学的飞速发展和基因治疗的日益进步,病毒载体越来越多应用于机制研究和临床前实验。本着服务于客户、服务于科研的宗旨,和元上海将病毒包装服务的稳定和质量作为公司首要目标。在材料质量、操作水平、质量控制等方面都建立了严格的内部标准,力争为客户提供高质量病毒和最准确的结果!

      一、公司介绍

            和元生物技术(上海)股份有限公司(简称“和元上海”,证券代码839702),2013年3月扎根于上海浦东,是一家集基础研究服务、基因治疗药物研发和临床级重组病毒产业化制备三大发展方向于一体的高新技术企业。自成立以来,和元始终秉承“整合你我资源,服务生命科学”的理念全力促进基因治疗从基础研究走向临床应用。
            以“打造一个平台,推动一个行业”为战略目标,和元长期致力于病毒载体的创新和产业化推进,已拥有基因治疗载体研发中心、SPF级动物实验室、中试工艺开发与生产实验室以及基于一次性技术的GMP级重组病毒车间。依托先进的重组病毒产业化生产、病毒载体修饰改造与包装,CRISPR/Cas9基因编辑、脑立体定位注射及成瘤模型构建等多种技术,和元人不断努力推动精准医疗细分行业的发展,为基因治疗行业的崛起提供有力平台。
            以“院校合作+科研服务+产业化支持”的商业模式,和元布局基因治疗行业产业链的各个阶段,并在生物医药领域提供优质的产品和技术服务。成立以来,和元每年保持30%的增长速度,已完成融资1亿元,成功构建15000多个人类表达基因cDNA库、20000多种病毒载体库、500多种人类肿瘤及正常细胞系,积累超过3000多家科研客户群,正在开展10多项临床试验IND申报及临床I/II期项目。拥有各项发明专利12件,成功注册商标等22件,获得上海市“小巨人培育”企业、上海市“专精特新”企业以及上海最具投资潜力50佳创业企业等荣誉。
          “让基因治疗造福人类”是和元的愿景和使命,我们始终坚持以基因治疗重组病毒载体研发及生产为核心,发展成为辐射全球的重组病毒药物生产CRO服务中心和基因药物生产CDMO/CMO基地,同时孵化基因治疗药物,让基因治疗真正造福人类!

      二、病毒载体服务介绍

            病毒载体是当前生物医学研究中重要的基因转导工具。一方面病毒载体经过改造具有更强的使用安全性和更快的分子克隆速度;另一方面,病毒的感染能力得到了定向的人工进化:治疗靶点筛选者希望得到更快捷,更广谱的转导工具,而基因治疗却需要更安全更特异的感染特性。在不断涌现的新工具新方法面前,研究者常常会无所适从,既难舍对已有系统的信赖与熟悉,又倾心于新工具的蓬勃前景。
            目前生物医学研究中常用的病毒载体包括腺相关病毒、慢病毒、腺病毒、逆转录病毒。表1简单的总结了四种病毒载体的基本生物学特性。和元慢病毒感染范围广,表达稳定长效,已经成为分子生物操作中的常规载体,越来越多的分子生物学技术与方法借助于慢病毒载体得以应用。腺病毒载体作为研究和使用时间最长的载体,虽然存在一些不足,但其特点依然鲜明,即感染速度快,基因装载量大。逆转录载体因其特殊的感染特性,仍在干细胞和血液细胞等分裂细胞研究中占有一席之地。而势头强劲的腺相关病毒因其极高的滴度和低转基因安全性,成为基因治疗研究的新宠儿。
      病毒相关技术服务:
       
      表1 不同病毒的生物学特性比较
       病毒特性 病毒类型
      慢病毒(LV) 逆转录病毒(RV) 腺相关病毒(AAV) 腺病毒(ADV)
      包膜
      颗粒直径 90-100 nm 90-100 nm 20-30 nm 60-90nm
      基因组 dsRNA dsRNA ssDNA dsDNA
      表达起始时间 48-72h 48-72h 72-96h 24-48h
      表达持续时间 > 2 months  > 2 months  > 6 months  < 1 month
      整合方式 随机高频整合 随机高频整合 定向低频整合 非整合

      1.腺相关病毒
            和元腺相关病毒(adeno-associated virus,AAV)是一类细小病毒,基因组为单链DNA,对分裂细胞和非分裂细胞均具有感染能力。 AAV的血清型是指目前已发现的不同衣壳蛋白的数十种AAV在体内产生不同的抗血清类型,它们对相同的组织和细胞具有不同的感染效率。
            重组腺相关病毒rAAV是利用AAV2型基因组与不同的衣壳蛋白结合产生的混合体病毒载体,一般标记为rAAV2/N (N为不同的衣壳血清型)。纽恩生物通过长期的研发,构建了一系列用于基因表达和基因干扰操作的载体。
       
      表2  不同血清型AAV的组织嗜亲性
      血清型 适用组织 胞外吸附分子
      AAV1 肌肉,心脏,神经 未知
      AAV2 体外,神经 硫酸乙酰肝素蛋白多糖
      AAV5 肺,眼睛,神经 N-唾液酸
      AAV6 肺,心脏 未知
      AAV7 肌肉,肝脏 未知
      AAV8 肝脏,肌肉,眼睛 未知
      AAV9 肺,肝脏,肌肉,心脏 未知
      rh10 肋膜,神经 未知

      病毒感染实例如下:
       
            
      2.慢病毒
            慢病毒(Lentivirus): 是一类改造自人免疫缺陷病毒(HIV)的病毒载体。它是一种RNA病毒,可利用逆转录酶将外源基因整合到基因组中实现稳定长时表达。目前广泛用于哺乳动物细胞和整体的基因转化操作,具有能同时感染分裂期与非分裂期的细胞等特性。
       
      病毒感染实例如下:
       
      3. 逆转录病毒
            逆转录病毒(Retrovirus) :改自鼠白血病病毒(MMLV),是一种RNA病毒,可以利用逆转录酶将外源基因整合到基因组中实现稳定长时表达。逆转录病毒特异性地感染分裂细胞,对造血干细胞和神经干细胞在体外和体内感染具有良好的效果。
       
      病毒感染实例如下:
       
      4. 腺病毒
            腺病毒 (Adenovirus) :是一种DNA病毒,具有广泛的细胞和组织感染能力。感染过程剧烈,适于在短时间内进行基因高表达的实验。与其它病毒载体相比,腺病毒最大优势在于插入片段较长,表达活性强;可进行扩增操作。
       
       病毒感染实例如下:

      三、客户部分发表文章列表

      [1] Nature. (IF=40.137). Yang Y,et.al. (2018). Ketamine blocks bursting in the lateral habenula to rapidly relieve depression. [腺相关病毒, 抑郁症].
      [2] Science. (IF=37.205). Mu D,et.al. (2017). A central neural circuit for itch sensation. [腺相关病毒, 痒].
      [3] Science. (IF=37.205). Zhou T,et.al. (2017). History of winning remodels thalamo-PFC circuit to reinforce social dominance. [腺相关病毒, 社会行为].
      [4] Science. (IF=37.205). Liu D,et.al. (2014). Medial prefrontal activity during delay period contributes to learning of a working memory task. [腺相关病毒, 学习与记忆, 光遗传].
      [5] Science. (IF=37.205). Li K,et.al. (2013). βCaMKII in lateral habenula mediates core symptoms of depression. [腺相关病毒, 抑郁症].
      [6] Cell. (IF=30.14). Zhu HY,et.al. (2018). Moderate UV Exposure Enhances Learning and Memory by Promoting a Novel Glutamate Biosynthetic Pathway in the Brain. [腺相关病毒, 学习与记忆].
      [7] Cell. (IF=30.14). Bian WJ,et.al. (2015). Coordinated Spine Pruning and Maturation Mediated by Inter-Spine Competition for Cadherin/Catenin Complexes. [腺相关病毒, 神经环路].
      [8] Nature Medicine. (IF=22.864). Zhu L J,et.al. (2014). CAPON-nNOS coupling can serve as a target for developing new anxiolytics. [腺相关病毒, 焦虑症].
      [9] Nature Medicine. (IF=22.864). Cao X,et.al. (2013). Astrocyte-derived ATP modulates depressive-like behaviors. [腺相关病毒, 抑郁症].
      [10] Nature Cell Biology. (IF=20.06). Wang Y J,et.al. (2017). Cholesterol and fatty acids regulate cysteine ubiquitylation of ACAT2 through competitive oxidation. [腺相关病毒, 脂质].
      [11] Cancer Discovery. (IF=19.783). Sun TT,et.al. (2016). A novel IncRNA GClnc1 promotes gastric carcinogenesis and may act as a modular scaffold of WDR5 and KAT2A complexes to specify the histone modification pattern. [腺病毒, 胃癌, lncRNA].
      [12] Nature Neuroscience. (IF=16.724). Ding XL,et.al. (2017). Activity-induced histone modifica-tions govern Neurexin-1 mRNA splicing and memory preservation. [慢病毒, 学习与记忆, 光遗传].
      [13] Nature Neuroscience. (IF=16.724). Li YD,et.al. (2017). A distinct entorhinal cortex to hippo-campal CA1 direct circuit for olfactory associative learning. [腺相关病毒, 学习与记忆].
      [14] Nature Neuroscience. (IF=16.724). Yang HB,et.al. (2015). Laterodorsal tegmentum interneu-ron subtypes oppositely regulate olfactory cue-induced innate fear. [腺相关病毒, 先天恐惧, 光遗传].
      [15] Nature Neuroscience. (IF=16.724). Zheng J J,et.al. (2013). Oxytocin mediates early expe-rience-dep Nature medicine endent cross-modal plasticity in the sensory cortices. [腺相关病毒, 感觉系统].
      [16] Science Translational Medicine. (IF=16.264). Shao J,et.al. (2017). Smartphone-controlled optogenetically engineered cells enable semiautomatic glucose homeostasis in diabetic mice. [慢病毒, 糖尿病].
      [17] Cell Research. (IF=15.606). Hu RG,et.al. (2017). Excessive UBE3A dosage impairs retinoic acid signaling and synaptic plasticity in autism spectrum disorders. [腺相关病毒, 孤独症].
      [18] Cell Research. (IF=14.812). Xie C,et.al. (2016). Genome editing with CRISPR/Cas9 in post-natal mice corrects PRKAG2 cardiac syndrome. [腺相关病毒, 心脏, Cas9].
      [19] Cell Research. (IF=14.812). Gao M,et.al. (2014). Generation of transgenic golden Syrian hamsters. [慢病毒, 转基因仓鼠].
      [20] Neuron. (IF=14.024). Han Q,et.al. (2018). A Visual-Cue-Dependent Memory Circuit for Place Navigation [腺相关病毒, 学习与记忆, 钙成像].
      [21] Neuron. (IF=14.024). Cao W,et.al. (2018). Gamma Oscillation Dysfunction in mPFC Leads to Social Deficits in Neuroligin 3 R451C Knockin Mice. [腺相关病毒, 自闭症, 光遗传].
      [22] Neuron. (IF=14.024). Wang Y,et.al. (2017). Depolarized GABAergic Signaling in Subicular Microcircuits Mediates Generalized Seizure in Temporal Lobe Epilepsy. [腺相关病毒, 癫痫, 光遗传].
      [23] Developmental Cell. (IF=12.681). Cheng T L,et.al. (2014). MeCP2 Suppresses Nuclear Mi-croRNA Processing and Dendritic Growth by Regulating the DGCR8/Drosha Complex. [腺相关病毒, 发育].
      [24] Nature Communications. (IF=12.124). Wei YC,et.al. (2018). Medial preoptic area in mice is capable of mediating sexually dimorphic behaviors regardless of gender. [腺相关病毒, 感觉系统].
      [25] Nature Communications. (IF=12.124). Xu L,et.al. (2017). The interhemispheric CA1 circuit governs rapid generalisation but not fear memory. [腺相关病毒, 学习与记忆, 光遗传 化学遗传].
      [26] Nature Communications. (IF=12.124). Yao XH,et.al. (2016). Electrical coupling regulates layer 1 interneuron microcircuit formation in the neocortex. [慢病毒, 神经环路].
      [27] Nature Communications. (IF=12.124). Wei PF,et.al. (2015). Processing of visually evoked innate fear by a non-canonical thalamic pathway. [腺相关病毒, 先天恐惧].
      [28] Nature Communications. (IF=12.124). Zhu YJ,et.al. (2015). Control of response reliability by parvalbumin-expressing interneurons in visual cortex. [腺相关病毒, 感觉系统, 视觉].
      [29] Nature Communications. (IF=12.124). Han G,et.al. (2016). Hexose enhances oligonucleotide delivery and exon skipping in dystrophin-deficient mdx mice. [腺相关病毒, 肌肉, 基因治疗].
      [30] Nature Communications. (IF=12.124). Shi Y,et.al. (2017). Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth. [慢病毒, 胶质细胞瘤干细胞].
      [31] Hepatology. (IF=11.711). Ma JZ,et.al. (2016). METTL14 suppresses the metastatic potential of HCC by modulating m6 A-dependent primary miRNA processing. [慢病毒, 肝癌].
      [32] The EMBO Journal. (IF=9.822). Ren S. Q,et.al. (2013). PKCλ is critical in AMPA receptor phosphorylation and synaptic incorporation during LTP. [腺相关病毒, 突触].
      [33] PNAS. (IF=9.674). Du H,et.al. (2016). Dopaminergic inputs in the dentate gyrus direct the choice of memory encoding. [腺相关病毒, 学习与记忆, 光遗传].
      [34] PNAS. (IF=9.674). Lia J,et.al. (2015). Synaptic P-Rex1 signaling regulates hippocampal longterm depression and autism-like social behavior. [腺相关病毒, 社会行为].
      [35] Elife. (IF=9.322). Niu Y,et.al. (2017). Ablation of SNX6 leads to defects in synaptic function of CA1 pyramidal neurons and spatial memory. [腺相关病毒, 学习与记忆].
      [36] Elife. (IF=9.322). Ni KM,et.al. (2016). Selectively driving cholinergic fibers optically in the thalamic reticular nucleus promotes sleep. [腺相关病毒, 睡眠].
      [37] Elife. (IF=9.322). Qu Z,et.al. (2016). Loss of ZBTB20 impairs circadian output and leads to unimodal behavioral rhythms. [腺相关病毒, 行为].
      [38] Elife. (IF=9.322). Chen M,et.al. (2015). Morphine disinhibits glutamatergic input to VTA do-pamine neurons and promotes dopamine neuron excitation. [腺相关病毒, 神经元兴奋性].
      [39] Autophagy. (IF=9.108). Shen Z,et.al. (2017). PARK2-dependent mitophagy induced by acidic postconditioning protects against focal cerebral ischemia and extends the reperfusion window. [腺相关病毒, 脑缺血, 自噬].
      [40] Autophagy. (IF=9.108). Zhao X J,et.al. (2015). Elaiophylin, a novel autophagy inhibitor, exerts antitumor activity as a single agent in ovarian cancer cells. [慢病毒, 卵巢癌, 自噬].
      [41] Autophagy. (IF=9.108). Guo W J,et.al. (2015). Small molecule-driven mitophagy-mediated NLRP3 inflammasome inhibition is responsible for the prevention of colitis-associated cancer. [慢病毒, 结肠炎相关癌症, 自噬].
      [42] Theranostics. (IF=8.854). Tao SC,et.al. (2017). Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in arat model. [慢病毒, 软骨, 外泌体].
      [43] Embo Molecular Medicine. (IF=8.665). Guan Y,et.al. (2016). CRISPR/Cas9-mediated somatic correction of anovel coagulator factor IX gene mutation ameliorates hemophilia in mouse. [腺病毒, 血友病, Cas9].
      [44] Biomaterials. (IF=8.402). Yang Q,et.al. (2017). Cuprous oxide nanoparticles trigger ER stress-inducedapoptosis by regulating copper trafficking and overcoming resistance to sunitinib therapy in renal cancer. [慢病毒, 肾].
      [45] Cell Reports. (IF=8.358). Wang B,et.al. (2016). FMRP-Mediated Axonal Delivery of miR-181d Regulates Axon Elongation by Locally Targeting Map1b and Calm1. [腺相关病毒, 突触传递].
      [46] Biomaterials. (IF=8.312). Luo X Y,et.al. (2015). CAD based design sensitivity analysis and shape optimization of scaffolds for bio-root regeneration in swine. [慢病毒, 生物牙根].
      [47] Biomaterials. (IF=8.312). Wang X,et.al. (2013). Promotion of dentin regeneration via CCN3 modulation on Notch and BMP signaling pathways. [慢病毒, 牙髓干细胞].
      [48] Cereb Cortex. (IF=8.285). Wu G Y,et.al. (2017). Medial Prefrontal Cortex-Pontine Nuclei Projections Modulate Suboptimal Cue-Induced Associative Motor Learning. [腺相关病毒, 学习与记忆].
      [49] Diabetes. (IF=8.095). Xiao Y Z,et.al. (2015). Activation of ERK1/2 ameliorates liver steatosis in leptin receptor deficient (db/db)mice via stimulating ATG7-dependent autophagy. [腺病毒, 肝脏].
      [50] Oncogene. (IF=7.932). Zhou Q ,et.al. (2016). Transducin (β)-like 1 X-linked receptor 1 pro-motes gastric cancer progression via the ERK1/2 pathway. [慢病毒, 胃癌].
      [51] Oncogene. (IF=7.932). Wen S Y,et.al. (2013). miR-506 acts as a tumor suppressor by directly targeting the hedgehog pathway transcription factor Gli3 in human cervical cancer. [慢病毒, 宫颈癌].
      [52] Clinical Cancer Research. (IF=7.837). Shi Y,et.al. (2014). Primate-specific miR-663 functions as a tumor suppressor by targeting PIK3CD and predicts the prognosis of human glioblastoma. [慢病毒, 胶质母细胞瘤].
      [53] Molecular Therapy. (IF=6.688). Yue B,et.al. (2018). A Positive Feed-Forward Loop between LncRNA-CYTOR and Wnt/β-Catenin Signaling Promotes Metastasis of Colon Cancer. [慢病毒, 结肠癌, lncRNA].
      [54] Diabetologia. (IF=6.671). Ma X,et.al. (2015). RBP4 functions as a hepatokine in the regulation of glucose metabolism by the circadian clock in mice. [腺相关病毒, 肝脏].
      [55] International Journal of Cancer. (IF=6.513). Ke Y,et.al. (2017). Discs large homolog 5 decreases formation and function of invadopodia in human hepatocellular carcinoma via Girdin and Tks5. [干扰质粒, 肝癌].
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