SerpinA5 / Protein C inhibitor

SerpinA5 / Protein C inhibitor 抗体产品信息

免疫原 :
Recombinant human SerpinA5 protein ( Catalog #10309-H08H )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, human cell-derived, recombinant human SerpinA5 (rhSerpinA5; Catalog#10309-H08H; aa 1-406; NP_000615.3). Total IgG was purified by Protein A affinity chromatography.
SerpinA5 / Protein C inhibitor 抗体背景综述
SerpinA5, also well known as protein C inhibitor (PCI), is a member of the human serpin superfamily. It is synthesized in the liver and has been detected in saliva, cerebral spinal fluid, amniotic fluid, tears and semen. SerpinA5 acts as a potent inhibitor of the protein C anticoagulant pathway at the levels of both zymogen activation and enzyme inhibition. SerpinA5 inhibits a variety of serine protease including thrombin, factor Xa, several kallekreins and acrosin. It plays a critical role in the processes of blood coagulation and fertilization. SerpinA5 also inhibits urinary plasminogen activator (uPA), a mediator of tumor cell invasion, and regulates tumor growth and metastasis by inhibiting angiogenesis. It is a potent and direct inhibitor of activated HGFA (hepatocyte growth factor activator).
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