JAML / AMICA抗体

JAML / AMICA抗体产品信息

免疫原 :
Recombinant Human JAML / AMICA protein (Catalog#10120-H08H)
Reagents : PE-conjugated mouse monoclonal antibody
Clone ID :
02
抗体宿主 :
Mouse IgG1
Concentration :
10 μl/Test, 0.1 mg/ml
缓冲液 : Aqueous solution containing 0.5% BSA and 0.09% sodium azide
制备方法 :
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human JAML / AMICA (rh JAML / AMICA; Catalog#10120-H08H; NP_001091996.1; Met 1-Leu 275) and conjugated with PE under optimum conditions, the unreacted PE was removed.
JAML / AMICA抗体 Background
JAML (Junctional adhesion molecule-like), also known as AMICA1 (Adhesion molecule interacting with CXADR antigen 1), is a member of JAM transmembrane protein family. It is composed of two extracellular immunoglobulin-like domains, a membrane-spanning region, and a cytoplasmic tail involved in activation signaling. The Expression of JAML is restricted to the hematopoietic tissues with the exception of liver. It is Expressed in fetal liver, spleen and thymus. JAML mediates adhesive interactions with Coxsackie virus and Adenovirus Receptor (CXADR in humans and CAR in mice),a protein which has been shown to localize to the tight junctions of epithelial cells. JAML mediated activation of CAR is required for neutrophil extravasation in addition to other leukocyte/epithelial cell interaction models. JAML may function in transmigration of leukocytes through epithelial and endothelial tissues. Expressed at the plasma membrane of polymorphonuclear leukocytes, JAML also enhances myeloid leukemia cell adhesion to endothelial cells.
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