SFTPD / SP-D / SFTP4抗体

SFTPD / SP-D / SFTP4抗体产品信息

免疫原 :
Recombinant Mouse SFTPD / SP-D / SFTP4 protein (Catalog#50205-M08H)
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 :
119
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse SFTPD / SP-D / SFTP4 (rM SFTPD / SP-D / SFTP4; Catalog#50205-M08H; NP_033186.1; Met1-Phe374).
SFTPD / SP-D / SFTP4抗体Background
Surfactant, pulmonary-associated protein D, also known as SFTPD and SP-D, is a member of the collectin family of C-type lectins that is synthesized in many tissues including respiratory epithelial cells in the lung, and contains one C-type lectin domain and one collagen-like domain. SP-D is assembled predominantly as dodecamers consisting of four set of homotrimers stabilized by interchain disulfide bonds involving two conserved amino-terminal cysteine residues. SP-D is produced primarily by alveolar type II cells and nonciliated bronchiolar cells in the lung and is constitutively secreted into the alveoli where it influences surfactant homeostasis, effector cell functions, and host defense. It is upregulated in a variety of inflammatory and infectious conditions including Pneumocystis pneumonia, asthma, and bleomycin injury. Mice or rats exposed to hyperoxic challenge also have increases in SP-D, suggesting that it may have a role in protection from this insult.
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