TRAIL R2 / TNFRSF10B / CD262抗体

TRAIL R2 / TNFRSF10B / CD262抗体产品信息

免疫原 :
Recombinant Mouse TRAIL R2 / TNFRSF10B / CD262 protein (Catalog#50412-M08H)
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 :
131
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse TRAIL R2 / TNFRSF10B / CD262 (rM TRAIL R2 / TNFRSF10B / CD262; Catalog#50412-M08H; NP_064671.2; Met 1-Ser 177).
TRAIL R2 / TNFRSF10B / CD262抗体 Background
TRAILR2, also known as DR5 and TNFRSF10B, is the fifth death domain-containing member of the TNFR family and a receptor for TRAIL/TNFSF10. TRAILR2 is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. This single-pass transmembrane protein contains two cysteine-rich repeat units in its extracellular region, followed by a predicted hydrophobic transmembrane segment and a 209 aa long cytoplasmic tail containing a typical "death domain". Upon ligand binding, the adapter molecule FADD recruits caspase-8 to the activated receptor TNFRSF10B. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis. TRAIL-R2 exhibits high structural and functional homology to TRAIL-R1 (DR-4), and TNFRSF10B expression is regulated by the tumor suppressor p53. Further, it is also indicated that the activation of NF-kappa-B can be promoted by TNFRSF10B.
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