CCN3 / NOV / IGFBP9抗体

CCN3 / NOV / IGFBP9抗体产品信息

免疫原 :
Recombinant Human CCN3 / NOV / IGFBP9 Protein (Catalog#10264-H08B)
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 :
130
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant Human CCN3 / NOV / IGFBP9 (rh CCN3 / NOV / IGFBP9; Catalog#10264-H08B ; NP_002505.1 ; Met 1- Met 357)
CCN3 / NOV / IGFBP9抗体 Background
Protein NOV homolog, also known as Nephroblastoma-overexpressed gene protein homolog, NOV, and CCN3, is secreted protein which belongs to the CCN family. CCN3 expression was observed in a broad variety of tissues from the early stage of development. It contains one CTCK (C-terminal cystine knot-like) domain, one IGFBP N-terminal domain, one TSP type-1 domain, and one VWFC domain. CCN3, a founding member of the CCN family of growth regulators, was linked with hematology in 2003 when it was detected in human serum. CCN3 acts through the core stem cell signalling pathways including Notch and Bone Morphogenic Protein, connecting CCN3 with the modulation of self-renewal and maturation of a number of cell lineages including hematopoietic, osteogenic and chondrogenic. Altered CCN3 expression is associated with numerous solid tumors including glioblastoma, melanoma, adrenocortical tumours, prostate cancer and bone malignancies including osteosarcoma. CCN3 may affect the extracellular environment of the niche for hematopoietic stem cells. CCN3 has emerged as a key player in stem cell regulation, hematopoiesis and a crucial component within the bone marrow microenvironment.
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