CNTN3 / BIG-1抗体

CNTN3 / BIG-1抗体产品信息

免疫原 :
Recombinant human CNTN3 protein ( Catalog#10174-H08H )
抗体类型: Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, human cell-derived, recombinant human Contactin-3 ( rhCNTN3; Catalog #10174-H08H; Met 1- Ser1002; NP_065923.1 ). Total IgG was purified by Protein A affinity chromatography.
CNTN3 / BIG-1抗体背景综述
CNTN3, also known as the brain-derived axon-associated cell adhesion molecule BIG-1 or PANG (plasmacytoma-associated neuronal glycoprotein), belongs to the contactin family consisting of six members (CNTN1/F3, CNTN2/TAG-1, CNTN3/BIG-1, CNTN4/BIG-2, CNTN5/NB-2 and CNTN6/NB-3). CNTN3 is a member of the immunoglobulin (Ig) superfamily with six Ig-like domains, four fibronectin type III-like repeats, and a GPI-anchoring domain. The expression pattern of CNTN3 is developmentally regulated with the highest level in the adult brain, and restricted to subsets of neurons such as Purkinje cells of the cerebellum, granule cells of the dentate gyrus, and neurons in the superficial layers of the cerebral cortex. CNTN3 has a neurite outgrowth-promoting activity. It plays an important role in the formation and maintenance of specific neuronal networks in the brain together with other contactin members.
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