4-1BBL / CD137L / TNFSF9抗体

4-1BBL / CD137L / TNFSF9抗体产品信息

免疫原 :
Recombinant Mouse 4-1BBL / CD137L / TNFSF9 protein (Catalog#50067-M07H)
Reagents : FITC-conjugated rabbit monoclonal antibody
Clone ID :
014
抗体宿主 :
Rabbit IgG
Concentration :
5 μl/Test, 0.2 mg/ml
缓冲液 : Aqueous solution containing 0.5% BSA and 0.09% sodium azide
制备方法 :
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse 4-1BBL / CD137L / TNFSF9 (rM 4-1BBL / CD137L / TNFSF9; Catalog#50067-M07H; NP_033430.1; Arg 104-Glu 309) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
4-1BBL / CD137L / TNFSF9抗体Background
4-1BB ligand (4-1BBL), also known as TNFSF9, is a member of the tumor necrosis factor (TNF) superfamily (TNFSF), and interacts with 4-1BB (CDw137) expressed on activated T cells and delivers a costimulatory signal for T cell activation and growth. Mouse 4-1BBL is a 309 amino acid (aa) residues protein with an 82 aa N-terminal cytoplasmic domain, a 21 aa transmembrane domain and a 206 aa C-terminal extracellular domain. The extracellular domain of 4-1BBL has a tertiary structure similar to that other TNFSF members, but shares only low aa sequence homology (14 - 16%). Murine 4-1BBL shares 36% aa sequence identity with its human counterpart which is detected in both T and B cells of human peripheral blood. 4-1BB ligand interacts with 4-1BB and co-stimulates the latter to secrete cytokines and to proliferate, and also this interaction modulates the effector CD4+ T cell-driven immune response and cytokine production in colitis without affecting regulatory T cell function.
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