TNFSF9 / 4-1BBL抗体

TNFSF9 / 4-1BBL抗体

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  • 询价
  • Merck millipore
  • 中国/美国/德国
  • hz-50067-RP01
  • 2025年07月16日
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    • 详细信息
    • 技术资料
    • 保存条件

      常温,避光

    • 克隆性

      单克隆

    • 抗体名

      TNFSF9 / 4-1BBL抗体

    TNFSF9 / 4-1BBL抗体产品信息

    免疫原 :
    Recombinant mouse TNFSF9 protein ( Catalog#50067-M07H )
    Ig Type : Rabbit IgG
    缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
    制备方法 :
    Produced in rabbits immunized with purified, human cell-derived, recombinant mouse TNFSF9 / 4-1BBL extracellular domain (rM TNFSF9; Catalog#50067-M07H; Arg 104-Glu 309; NP_033430.1). Total IgG was purified by Protein A affinity chromatography.
    TNFSF9 / 4-1BBL抗体 Background
    4-1BB ligand (4-1BBL), also known as TNFSF9, is a member of the tumor necrosis factor (TNF) superfamily (TNFSF), and interacts with 4-1BB (CDw137) expressed on activated T cells and delivers a costimulatory signal for T cell activation and growth. Mouse 4-1BBL is a 309 amino acid (aa) residues protein with an 82 aa N-terminal cytoplasmic domain, a 21 aa transmembrane domain and a 206 aa C-terminal extracellular domain. The extracellular domain of 4-1BBL has a tertiary structure similar to that other TNFSF members, but shares only low aa sequence homology (14 - 16%). Murine 4-1BBL shares 36% aa sequence identity with its human counterpart which is detected in both T and B cells of human peripheral blood. 4-1BB ligand interacts with 4-1BB and co-stimulates the latter to secrete cytokines and to proliferate, and also this interaction modulates the effector CD4+ T cell-driven immune response and cytokine production in colitis without affecting regulatory T cell function.
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