Granulin / Progranulin / GRN抗体

Granulin / Progranulin / GRN抗体产品信息

免疫原 :
Recombinant Mouse Granulin / Progranulin / GRN protein (Catalog#50396-M08H)
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 :
017
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse Granulin / Progranulin / GRN (rM Granulin / Progranulin / GRN; Catalog#50396-M08H; NP_032201.2; Met 1-Leu 589).
Granulin / Progranulin / GRN抗体 Background
Granulin (GRN), also known as PC cell derived growth factor (PCDGF), is a ubiquitously expressed 88 kDa secreted, glycosylated protein which contains seven tandem repeats (55-57 aa consensus) of a highly conserved 12-cysteine granulin/epithelin motif. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Both the peptides and intact granulin protein regulate cell growth. Different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth, and thus perform important functions in normal development, wound healing, and tumorigenesis.Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD), an autosomal dominant neurodegenerative.
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