PD-L2 / CD273 / B7-DC抗体

PD-L2 / CD273 / B7-DC抗体产品信息

免疫原 :
Recombinant human PD-L2 protein ( Catalog#10292-H08H )
Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 :
18
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant human PD-L2 / CD273 ( rh PD-L2 ; Catalog#10292-H08H; NP_079515.2; Met 1- Pro 219 ).
PD-L2 / CD273 / B7-DC抗体背景综述
Programmed death ligand 2 (PD-L2), also referred to as B7-DC and CD273, is a member of the B7 family of proteins including B7-1, B7-2, B7-H2, B7-H1 (PD-L1), and B7-H3. PD-L2 and PD-L1 are two ligands for PD-1, member of the CD28/CTLA4 family expressed on activated lymphoid cells, and thus provide signals for regulating T cell activation and immune tolerance. The interaction of B7-DC / PD-1 exhibited a 2-6-fold higher affinity compared with the interaction of B7-H1 / PD-1. PD-L2 is a type I membrane protein and structurally consists of an extracellular region containing one V-like and one C-like Ig domain, a transmembrane region, and a short cytoplasmic domain. PD-L2 is expressed on antigen presenting cells, placental endothelium and medullary thymic epithelial cells, and can be induced by LPS in B cells, INF-γ in monocytes, or LPS plus IFN-γ in dendritic cells. It has been demonstrated that on human T cells, PD-L2 acts only as a negative regulator of T cell activity by inhibiting T-cell proliferation and cytokine production, involving modulation of the PI3-K / AKT and ERK / MAPK pathways.
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