Granulin / GRN抗体

Granulin / GRN抗体产品信息

免疫原 :
Recombinant human GRN protein ( Catalog#10826-H08H )
抗体类型: Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, human cell-derived, recombinant human GRN / Granulin ( rh GRN; Catalog#10826-H08H; Met 1-Leu 593; NP_002078.1 ). GRN specific IgG was purified by human GRN affinity chromatography.
Granulin / GRN抗体背景综述
Granulin (GRN), also known as PC cell derived growth factor (PCDGF), is a ubiquitously expressed glycosylated protein which contains seven tandem repeats (55-57 aa consensus) of a highly conserved 12-cysteine granulin/epithelin motif. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Both the peptides and intact granulin protein regulate cell growth. Different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth, and thus perform important functions in normal development, wound healing, and tumorigenesis. Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD), an autosomal dominant neurodegenerative.
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