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- xy50220-RP02
- 2025年07月15日
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- 技术资料
- 保存条件：
常温，避光
- 克隆性：
单克隆
- 抗体名：
MCPT-1 / MCP-1抗体
抗体类型: Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, human cell-derived, recombinant mouse MCPT1 ( rM MCPT1; Catalog#50220-M08H ; NP_032596.1; Met 1- Lys 246 ). MCPT1 specific IgG was purified by mouse MCPT1 affinity chromatography.
MCPT-1 / MCP-1抗体背景综述
Mouse Mast Cell Protease 1 (MMCP-1) , also known as MCP-1, MCPT-1 and β-chymase, is a member of the Chymase family of chymotrypsin-like serine proteases. It is a β-chymase that is a component of mast cell granules. MCPT-1 is a protein that has a conserved pattern of six cysteines and one potential glycosylation site. Mature mouse and rat MCPT-1 share 76% aa identity. MCPT-1 is predominantly expressed in intestinal mucosal mast cells where it promotes mucosal permeability in intestinal allergic hypersensitivity reactions. Its activation is completed by the removal of a two residue N-terminal propeptide by a dipeptidyl peptidase (Cathepsin C). MCPT-1 is upregulated in the intestine in response to nematode infection, or in systemic mucosa in response to anaphylaxis. Like human α-chymase, MCPT-1 is capable of the conversion of angiotensin I to angiotensin II, which plays a key role in the regulation of arterial pressure.
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文献和实验乙型肝炎、和HBsAg阳性的患者血清中前S1蛋白，前S1抗原阴转愈早，AHB患者的疗程愈短，预后也愈好。说明前S1抗原及其抗体的检测是急性乙型肝炎的临床诊断，疗效观察和判数据预后的良好指标。 前S1蛋白的分子生物学特性 1．乙肝病毒（HBV）的基因结构 HBV为嗜肝DNA病毒，由一个不完全双链DNA组成，约3200个氨基酸。长链L含4个开放读码框架，为病毒蛋白的编码区：S区、C区、P区、X区。短链S相当于长链的50%-100%，其不固定端可被内原性DNA多聚酶延长，使病毒成为完整
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