MCPT-1 / MCP-1抗体

MCPT-1 / MCP-1抗体产品信息

免疫原 :
Recombinant mouse MCPT1 protein ( Catalog#50220-M08H )
抗体类型: Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, human cell-derived, recombinant mouse MCPT1 ( rM MCPT1; Catalog#50220-M08H ; NP_032596.1; Met 1- Lys 246 ). Total IgG was purified by Protein A affinity chromatography.
MCPT-1 / MCP-1抗体 Background
Mouse Mast Cell Protease 1 (MMCP-1) , also known as MCP-1, MCPT-1 and β-chymase, is a member of the Chymase family of chymotrypsin-like serine proteases. It is a β-chymase that is a component of mast cell granules. MCPT-1 is a protein that has a conserved pattern of six cysteines and one potential glycosylation site. Mature mouse and rat MCPT-1 share 76% aa identity. MCPT-1 is predominantly expressed in intestinal mucosal mast cells where it promotes mucosal permeability in intestinal allergic hypersensitivity reactions. Its activation is completed by the removal of a two residue N-terminal propeptide by a dipeptidyl peptidase (Cathepsin C). MCPT-1 is upregulated in the intestine in response to nematode infection, or in systemic mucosa in response to anaphylaxis. Like human α-chymase, MCPT-1 is capable of the conversion of angiotensin I to angiotensin II, which plays a key role in the regulation of arterial pressure.
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