ICOSLG / B7-H2 / ICOSL抗体

ICOSLG / B7-H2 / ICOSL抗体产品信息免疫原 : Recombinant human ICOSLG protein ( Catalog#11559-H08H )

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG

缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, human cell-derived, recombinant human ICOSLG ( rh ICOSLG ; Catalog#11559-H08H ; NP_056074.1 ; Met 1 - Ser 258 ). Total IgG was purified by Protein A affinity chromatography
ICOSLG / B7-H2 / ICOSL抗体背景综述
Inducible co-stimulator ligand ( ICOSL ), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains, and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. Present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. ICOSL constructs lacking either the IgC or IgV domain demonstrates that receptor binding is mediated solely by the IgV domain but requires the IgC domain for maintaining the structural integrity of the protein. The receptor binding site on ICOSL is constituted chiefly by aromatic / hydrophobic residues.
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