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- 详细信息
- 文献和实验
- 技术资料
- 英文名:
Recombinant Human Vitamin D Receptor
- 供应商:
艾美捷科技有限公司
- 规格:
5ug&20ug&1mg
【产品形式】:艾美捷为您提供的【VDR】重组人维生素D受体蛋白产品是经无菌过滤处理的无色溶液。
【背景资料】:Vitamin D receptors (VDRs) belong to the NR1I family, which also includes pregnane X (PXR) and constitutive androstane (CAR) receptors which form heterodimers with members of the retinoid X receptor family. VDR is expressed in the intestine, thyroid and kidney and has an imperative role in calcium homeostasis. VDRs inhibit expression of 1alpha-hydroxylase (the proximal activator of 1,25(OH)2D3 and induce expression of the 1,25(OH)2D3 inactivating enzyme CYP24. Additionally, VDR has recently been recognized as an additional bile acid receptor alongside FXR and may function to protect gut against the toxic and carcinogenic effects of these endobiotics. Hereditary mutations in the VDR gene leads to rickets, which is typified by muscle weakness, growth retardation, bone deformity and secondary hyperparathyroidism. The human gene encoding the VDR is localized to chromosome 12q12-q14.
以色列ProSpec-Tany公司专注于细菌来源重组蛋白质生产。其独有细菌和哺乳动物表达和蛋白折叠技术使其成为国际一流科研级蛋白供应商。ProSpec-Tany是世界上能提供蛋白种类最多公司之一。领先生产工艺和规模使其可以提供毫克到克级蛋白,价格优于同类公司。作为多家知名品牌代理,艾美捷与ProSpec一起为研究者们提供最好、最新细胞生物学研究工具而不断扩大产品及服务质量。更多特色试剂盒、特色抗体以及特色试剂等产品评论,请点击查看中国生命科学试剂产品评论网站。
点击【VDR】重组人维生素D受体查看更详细产品说明,更多应用、储存、价格、货期等信息请致电400-6800-1454垂询Prospec中国区域授权总代理艾美捷科技有限公司。
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文献和实验Human vitamin D receptor (hVDR) belongs to the superfamily of steroid receptors. The receptors are nuclear transcription factors that regulate gene expression in response to binding of their specific ligands. According to present knowledge
The discovery of hepatitis B virus (HBV) four decades ago initiated the progressive increase in knowledge of an important hepatotropic infectious agent that culminated in the design of the first successful recombinant vaccine for a human
黑色素瘤治疗最新发现:维生素 D 能抑制 Wnt/beta-catenin 信号通路,降低癌细胞的侵袭能力
,哥本哈根大学的 Carsten Geisler 教授和他的团队就曾在 Nature Immunology 上发表过有关维生素 D 的免疫作用的研究成果,题为 《Vitamin D controls T cell antigen receptor signaling and activation of human T cells》。研究人员发现 T 细胞受体信号转导过程能够通过 p38/MAPK 通路上调 T 细胞中的维生素 D 受体(VDR)表达。而且 T 细胞中的重要信号传递因子 PLC-gamma
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