【NR1H2】重组人核受体亚家族1,H组,成员2 | Rec

【产品形式】：艾美捷为您提供的【NR1H2】重组人核受体亚家族1,H组,成员2蛋白产品是冻干粉末。建议用无菌处理的18M-cm水溶解重组人核受体亚家族1,H组,成员2，浓度不低于100ug/ml。后继实验过程中可根据实验要求进一步稀释。

【背景资料】：NR1H2 regulates the metabolism of cholesterol and bile acids. There are 2 subtypes of LXR, LXR-alpha & LXR-beta. NR1H2 is a ligand-dependent transcription factor that forms heterodimer with the retinoid X receptor. LXR- member of Nuclear Receptor Family is triggered by specific oxysterol derivatives of cholesterol. LXRB takes part in cholesterol, lipid, and carbohydrate metabolism. LXRB responds to increasing cholesterol levels via transactivation of genes involved in sterol transport (ABCA1, ABCG1, ABCG5, and ABCG8), cholesterol efflux and high-density lipoprotein (HDL) metabolism, and sterol catabolism (CYP7A1). NR1H2 is involved in regulating cellular lipid content through activation of SREBP-1c, which is the principal regulator of de novo lipogenesis. LXRB upregulates angiopoietin like protein 3 (Angpf13), part of the family of VEGFs that is also a main regulator of lipid metabolism.

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