ISG15 E1 蛋白(人) | ISG15 E1 prot

【产品形式】：艾美捷为您提供的ISG15 E1 蛋白(人)形式为50mM Tris-Cl, pH7.5, 50mM NaCl, 1mM DTT

【背景资料】：ISG15 is an interferon (IFN)-alpha/beta-induced ubiquitin-like protein that is conjugated to cellular proteins during innate immune responses to bacterial and viral infections, including HIV. Conjugation of ISG15 to cellular proteins occurs in a parallel but distinct mechanism to that of ubiquitin. The E1 activating enzyme for ISG15, is a single-subunit, ATP dependent enzyme, also known as Ube1L showing a high level of similarity to the E1 activating enzyme for ubiquitin at the protein level. However, this protein does not form a conjugate with ubiquitin, indicating that Ube1L is an E1 enzyme for the ISG15 conjugation system (ISGylation). UbcH8, a member of the ubiquitin E2-conjugating enzyme family, has been identified as a major E2 enzyme for the ISGylation pathway, interacting with Ube1L to facilitate target protein ISGylation. As for ISG15 and Ube1L, UbcH8 expression is induced by IFN. A number of target proteins conjugated with ISG15 have been identified along with HERC5, an IFN-induced HECT domain-containing E3 protein ligase, shown to be responsible for mediation of cellular protein ISGylation, and itself a target for modification by ISG15.

英国Viva Bioscience公司是一家研发、生产并销售蛋白降解相关产品的公司。其产品主要用于细胞自噬、泛素化和蛋白酶体研究（也覆盖其他蛋白降解相关的产品），其产品价格合理、质量可靠且具有创新性。目前VIVA Bioscience提供逾460种产品，涉及细胞自噬、蛋白泛素化和讲解相关的所有试剂盒、蛋白、底物以及多种抑制剂、激活剂等全系列产品。作为多家进口品牌的中国区域总代理，艾美捷科技与Viva Bioscience一道为中国科研工作者们提供更好、更新的自噬、泛素化和蛋白酶体等研究工具。

点击ISG15 E1 蛋白(人)查看更详细产品说明，更多应用、储存、价格、货期等信息请致电垂询Viva Bioscience中国区域授权总代理艾美捷科技有限公司。